富含组氨酸的糖蛋白作为脓毒症及其它疾病的优秀生物标志物。
Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond.
机构信息
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Department of Anesthesiology & Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
出版信息
Crit Care. 2018 Aug 17;22(1):209. doi: 10.1186/s13054-018-2127-5.
Abstract
Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatment at an earlier stage of the disease course. We propose that decreases in the plasma protein histidine-rich glycoprotein (HRG) is an excellent biomarker of sepsis compared with the current markers. Based on the novel pathophysiological roles of HRG in the cascade of events during sepsis, we also discuss the potential for supplemental therapy with purified HRG.
摘要
脓毒症仍然是一个全球性的严重问题，具有高发病率和死亡率。我们在重症监护中面临的问题之一是需要找到一种良好的脓毒症生物标志物，以确定细菌感染的存在和患者的严重程度。这将使我们能够在疾病过程的早期阶段开始进行适当的治疗。我们提出，与当前标志物相比，血浆蛋白组氨酸丰富糖蛋白（HRG）的减少是脓毒症的一个极好的生物标志物。基于 HRG 在脓毒症事件级联反应中的新的病理生理学作用，我们还讨论了用纯化的 HRG 进行补充治疗的可能性。
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