Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
J Nucl Cardiol. 2019 Dec;26(6):1974-1980. doi: 10.1007/s12350-018-1402-9. Epub 2018 Aug 17.
To determine the influence of weight, height, gender, age, heart rate, and blood pressure on count rate in cadmium-zinc-telluride single-photon emission computed tomography (CZT SPECT) gated radionuclide angiography.
A total of 1,065 eligible patients referred for routine assessment of left ventricular ejection fraction were registered from August 2015 to November 2016. Data were recorded on heart rate, systolic and diastolic blood pressure, age, gender, height, weight, and count rate. All radionuclide angiographies were performed on a dedicated cardiac CZT SPECT camera, GE Discovery 530c. A dose of 550 MBq Tc-labeled human serum albumin was administered intravenously to each patient.
Count rate varied from 1.2 to 8.9 counts per second. All test variables were significantly associated with count rate. From the preliminary analysis, weight appeared as the main contributing factor for explaining the variations in count rate with and R of 0.68. A model consisting of weight, height, gender, and age explains 75% of the variance in count rate.
Patient height, weight, gender, and age have significant impact on count rate when performing CZT radionuclide angiography and may subsequently be used for individualized planning of tracer dosage.
确定体重、身高、性别、年龄、心率和血压对镉锌碲单光子发射计算机断层扫描（CZT SPECT）门控放射性核素血管造影计数率的影响。
2015 年 8 月至 2016 年 11 月，共登记了 1065 名符合条件的患者，这些患者是为常规评估左心室射血分数而就诊的。记录了心率、收缩压和舒张压、年龄、性别、身高、体重和计数率的数据。所有放射性核素血管造影均在专用心脏 CZT SPECT 相机（GE Discovery 530c）上进行。向每位患者静脉注射 550MBq Tc 标记的人血清白蛋白。
计数率从 1.2 到 8.9 计数/秒不等。所有测试变量均与计数率显著相关。初步分析显示，体重似乎是解释计数率变化的主要因素，与 R 为 0.68。由体重、身高、性别和年龄组成的模型可以解释计数率 75%的差异。
在进行 CZT 放射性核素血管造影时，患者的身高、体重、性别和年龄对计数率有显著影响，因此可能用于个体化计划示踪剂剂量。
