单克隆抗体对小鼠致死性肝炎病毒感染的保护作用
Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice.
作者信息
Nakanaga K, Yamanouchi K, Fujiwara K
出版信息
J Virol. 1986 Jul;59(1):168-71. doi: 10.1128/JVI.59.1.168-171.1986.
Abstract
Neutralizing and nonneutralizing monoclonal antibodies to the peplomer glycoprotein and nucleocapsid protein of a mouse hepatitis virus (MHV), MHV-NuU, protected mice against lethal MHV-2 challenge. Histopathologically, livers of mice receiving protective antibodies showed some focal necrotic lesions with remarkable cellular infiltration instead of fulminant hepatitis caused by MHV-2.
摘要
针对小鼠肝炎病毒（MHV）MHV-NuU的纤突糖蛋白和核衣壳蛋白的中和及非中和单克隆抗体可保护小鼠免受致死性MHV-2攻击。从组织病理学角度来看，接受保护性抗体的小鼠肝脏出现了一些局灶性坏死病变，并伴有明显的细胞浸润，而非MHV-2所致的暴发性肝炎。
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