Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA,
Division of Pulmonary, Critical Care & Sleep Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Clin Interv Aging. 2018 Aug 1;13:1353-1364. doi: 10.2147/CIA.S134919. eCollection 2018.
With the number of individuals older than 65 years expected to rise significantly over the next few decades, dramatic changes to our society and health care system will need to take place to meet their needs. Age-related changes in muscle mass and body composition along with medical comorbidities including stroke, dementia, and depression place elderly adults at high risk for developing malnutrition and frailty. This loss of function and decline in muscle mass (ie, sarcopenia) can be associated with reduced mobility and ability to perform the task of daily living, placing the elderly at an increased risk for falls, fractures, and subsequent institutionalization, leading to a decline in the quality of life and increased mortality. There are a number of modifiable factors that can mitigate some of the muscle loss elderly experience especially when hospitalized. Due to this, it is paramount for providers to understand the pathophysiology behind malnutrition and sarcopenia, be able to assess risk factors for malnutrition, and provide appropriate nutrition support. The present review describes the pathophysiology of malnutrition, identifies contributing factors to this condition, discusses tools to assess nutritional status, and proposes key strategies for optimizing enteral nutrition therapy for the elderly.
随着未来几十年 65 岁以上人口数量的显著增加,我们的社会和医疗保健系统将需要发生重大变化,以满足他们的需求。肌肉质量和身体成分的与年龄相关的变化以及包括中风、痴呆和抑郁症在内的医疗合并症使老年人极易发生营养不良和虚弱。这种功能丧失和肌肉质量下降(即肌少症)可导致活动能力下降和日常生活活动能力下降,使老年人跌倒、骨折和随后住院的风险增加,导致生活质量下降和死亡率增加。有许多可改变的因素可以减轻老年人在住院期间经历的一些肌肉损失。因此,对于医疗保健提供者来说,了解营养不良和肌少症背后的病理生理学、能够评估营养不良的风险因素以及提供适当的营养支持至关重要。本综述描述了营养不良的病理生理学,确定了导致这种情况的因素,讨论了评估营养状况的工具,并提出了优化老年人肠内营养治疗的关键策略。