编码糖蛋白gH的单纯疱疹病毒1型基因的DNA序列，以及水痘-带状疱疹病毒和爱泼斯坦-巴尔病毒基因组中同源物的鉴定。
DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus.
作者信息
McGeoch D J, Davison A J
出版信息
Nucleic Acids Res. 1986 May 27;14(10):4281-92. doi: 10.1093/nar/14.10.4281.
Abstract
We have determined the sequence of herpes simplex virus type 1 DNA around the previously mapped location of sequences encoding an epitope of glycoprotein gH, and have deduced the structure of the gH gene and the amino acid sequence of gH. The unprocessed polypeptide is predicted to contain 838 amino acids, and to possess an N-terminal signal sequence and a C-terminal transmembrane sequence. Temperature-sensitive mutant tsQ26 maps within the predicted gH coding sequence. Homologous genes were identified in the genomes of two other herpesviruses, namely varicella-zoster virus and Epstein-Barr virus.
摘要
我们已经确定了单纯疱疹病毒1型DNA在先前绘制的编码糖蛋白gH一个表位的序列位置周围的序列，并推导了gH基因的结构和gH的氨基酸序列。预计未加工的多肽含有838个氨基酸，并具有一个N端信号序列和一个C端跨膜序列。温度敏感突变体tsQ26位于预测的gH编码序列内。在另外两种疱疹病毒，即水痘带状疱疹病毒和爱泼斯坦-巴尔病毒的基因组中鉴定出了同源基因。
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