Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York.
Department of Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland.
J Infect Dis. 2018 Aug 14;218(suppl_1):S7-S11. doi: 10.1093/infdis/jiy083.
The Damage-Response Framework (DRF) is a powerful tool to inform research in infectious diseases. It can integrate clinical observation with microbiology and immunology to incorporate the role of the host response into the outcome of microbial pathogenesis. Although the role that microbial factors may play in the pathogenesis of infectious diseases is well recognized, the DRF brings the indispensable role of the host response to the fore. For example, inflammation may induce microbial control, but it can also produce host damage. On the other hand, insufficient inflammation may fail to induce sufficient microbial control. Each scenario may lead to the diagnosis of an infectious disease. Given the central role that the host response plays in the pathogenesis of infectious diseases, new strategies for treatment need to consider the nature of the host response as well as microbial factors.
损伤-反应框架（DRF）是一种强大的工具，可以为传染病研究提供信息。它可以将临床观察与微生物学和免疫学相结合，将宿主反应的作用纳入微生物发病机制的结果中。虽然人们已经认识到微生物因素在传染病发病机制中可能发挥的作用，但 DRF 使宿主反应的不可或缺作用更加突出。例如，炎症可能会诱导微生物控制，但也会产生宿主损伤。另一方面，炎症不足可能无法引起足够的微生物控制。每种情况都可能导致传染病的诊断。鉴于宿主反应在传染病发病机制中的核心作用，新的治疗策略需要考虑宿主反应的性质以及微生物因素。
