Shimoyama M, Kagami Y, Shimotohno K, Miwa M, Minato K, Tobinai K, Suemasu K, Sugimura T
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4524-8. doi: 10.1073/pnas.83.12.4524.
We describe five patients with adult T-cell leukemia/lymphoma (ATL) with neither integration of human T-cell leukemia virus type I (HTLV-I) into their leukemia cells nor anti-HTLV-I antibody in their sera. These findings indicate that HTLV-I may not have been involved in leukemogenesis in these patients. The clinicohematological, cytopathological, and immunological features of HTLV-I-negative ATL were exactly the same as those of HTLV-I-associated ATL. Leukemia cells with pleomorphic nuclei, generalized lymphadenopathy, hepatosplenomegaly, skin lesions, hypercalcemia, and elevated lactate dehydrogenase levels, all of which are characteristic features of typical ATL, were also seen in these patients with HTLV-I-negative ATL. Leukemia cells expressed T3, T4, and pan-T-cell antigens in three cases, and T3 and pan-T-cell antigens in two. All five patients had lived in ATL-nonendemic areas. The finding of HTLV-I-negative ATL suggests that factor(s) other than HTLV-I infection may be involved in ATL leukemogenesis.
我们描述了5例成人T细胞白血病/淋巴瘤（ATL）患者，其白血病细胞中无人T细胞白血病病毒I型（HTLV-I）整合，血清中也无抗HTLV-I抗体。这些发现表明HTLV-I可能未参与这些患者的白血病发生。HTLV-I阴性ATL的临床血液学、细胞病理学和免疫学特征与HTLV-I相关ATL完全相同。这些HTLV-I阴性ATL患者也出现了具有多形核的白血病细胞、全身淋巴结肿大、肝脾肿大、皮肤病变、高钙血症以及乳酸脱氢酶水平升高，所有这些都是典型ATL的特征性表现。3例白血病细胞表达T3、T4和泛T细胞抗原，2例表达T3和泛T细胞抗原。所有5例患者均生活在ATL非流行地区。HTLV-I阴性ATL的发现提示，除HTLV-I感染外，其他因素可能参与了ATL的白血病发生。
