Department of Gastroenterology, Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Adv Exp Med Biol. 2021;1316:25-39. doi: 10.1007/978-981-33-6785-2_2.
Lipids have many critical biological functions in cancer. There are characteristic changes of lipid metabolism and metabolites in different physiological and pathological processes. Lipidomics is an emerging discipline of metabolomics for systematic analysis of lipids in organisms, tissues, or cells and the molecules that interact with them. With the development of new analytical techniques, especially the application and development of mass spectrometry techniques, the determination of lipids can be carried out quickly and accurately and has a high throughput. A large number of studies have shown that abnormal lipid metabolism is closely related to the occurrence and development of tumors. The application of lipidomics technology can reveal changes in lipids and relative abnormal metabolic pathways associated with tumors. Moreover, it shows a wide range of application prospects in the identification of tumor lipid biomarkers, early tumor diagnosis, and the discovery of antitumor drug targets. This chapter mainly introduces the application and development direction of lipidomics in the diagnosis and therapy of different tumors.
脂质在癌症中有许多重要的生物学功能。在不同的生理和病理过程中，脂质代谢和代谢物会发生特征性变化。脂质组学是代谢组学的一个新兴分支，用于系统分析生物、组织或细胞中的脂质以及与之相互作用的分子。随着新分析技术的发展，特别是质谱技术的应用和发展，脂质的测定可以快速、准确地进行，并且具有高通量。大量研究表明，异常的脂质代谢与肿瘤的发生和发展密切相关。脂质组学技术的应用可以揭示与肿瘤相关的脂质变化和相对异常的代谢途径。此外，它在肿瘤脂质生物标志物的鉴定、早期肿瘤诊断和抗肿瘤药物靶点的发现方面具有广泛的应用前景。本章主要介绍脂质组学在不同肿瘤的诊断和治疗中的应用和发展方向。
