Department of Epidemiology and Biostatistics, Key Laboratory of Environment and Health of Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, 315211, China.
Curr Med Sci. 2018 Aug;38(4):610-617. doi: 10.1007/s11596-018-1921-2. Epub 2018 Aug 20.
Studies concerning the association between arsenic exposure and hepatitis B virus (HB V) infection have been lacking. The present study aimed to examine the association between total urinary arsenic (TUA) and infection of HBV. A total of 5186 participants from National Health and Nutrition Examination Survey (NHANES) 2003-2014 were included in the analysis. We used logistic regression to evaluate the association. We defined two measures of TUA. TUAI was the sum of arsenous acid, arsenicacid, monomethylarsonic acid and dimethylarsenic acid. TUA2 was defined as TUA minus arsenobetaine and arsenocholine. The results showed that the weighted overall prevalence of HBV infection was 6.08%. For NHANES 2003-2014, the medians (interquartile range) of TUAI and TUA2 were 5.60 μg/L (3.97-8.09 μg/L) and 4.91 μg/L (2.36-9.11 μg/L), respectively. Comparing the highest quartile to the lowest quartile after multivariable adjustment showed that the odds ratios (ORs) and 95% confidence intervals (CIs) for TUAI and TUA2 were 2.44 (1.40-4.27) and 2.84 (1.60-5.05), respectively. In conclusion, elevated urinary arsenic was associated with the risk of HBV infection. Further studies, especially prospective studies, are needed to confirm the causal relationship between arsenic exposure and HBV infection.
关于砷暴露与乙型肝炎病毒（HBV）感染之间关联的研究较少。本研究旨在探讨总尿砷（TUA）与 HBV 感染之间的关系。共纳入了来自国家健康和营养调查（NHANES）2003-2014 年的 5186 名参与者进行分析。我们使用 logistic 回归评估关联。我们定义了两种 TUA 测量方法。TUAI 是砷酸、砷酸、一甲基砷酸和二甲基砷酸的总和。TUA2 定义为 TUA 减去砷甜菜碱和砷胆碱。结果显示，HBV 感染的加权总患病率为 6.08%。对于 NHANES 2003-2014 年，TUAI 和 TUA2 的中位数（四分位距）分别为 5.60μg/L（3.97-8.09μg/L）和 4.91μg/L（2.36-9.11μg/L）。在多变量调整后，比较最高四分位数与最低四分位数，TUAI 和 TUA2 的比值比（ORs）和 95%置信区间（CIs）分别为 2.44（1.40-4.27）和 2.84（1.60-5.05）。总之，尿砷升高与 HBV 感染风险增加相关。需要进一步的研究，特别是前瞻性研究，来证实砷暴露与 HBV 感染之间的因果关系。
