Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.
Immunol Rev. 2018 Sep;285(1):81-96. doi: 10.1111/imr.12687.
Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward understanding this virus, particularly the immune mechanisms responsible for rapid viral control in the majority of infections. Identifying and understanding the key mechanisms of immune control will provide the foundation for the development of effective vaccines and antiviral therapy. Here, we outline a mathematical modeling approach for analyzing the within-host dynamics of Zika virus, and we describe how these models can be used to understand key aspects of the viral life cycle and to predict antiviral efficacy.
最近的寨卡病毒爆发与严重后果有关，尤其是在怀孕期间。人们投入了大量精力来了解这种病毒，特别是了解负责大多数感染中快速病毒控制的免疫机制。确定和了解免疫控制的关键机制将为开发有效疫苗和抗病毒疗法提供基础。在这里，我们概述了一种用于分析寨卡病毒体内动力学的数学建模方法，并描述了如何使用这些模型来了解病毒生命周期的关键方面并预测抗病毒功效。
