简报：从受孕前到怀孕期间的产妇阿片类药物处方与儿童自闭症谱系障碍和自闭症特征的关联。
Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children.
机构信息
Waisman Center, University of Wisconsin-Madison, Rm 529, 1500 Highland Avenue, Madison, WI, 53705, USA.
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.
出版信息
J Autism Dev Disord. 2019 Jan;49(1):376-382. doi: 10.1007/s10803-018-3721-8.
Abstract
Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child's risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.
摘要
孕期使用阿片类药物与不理想的妊娠结局有关。关于儿童神经发育结局知之甚少。我们研究了母亲在受孕前至分娩期间（围孕期）开具的阿片类药物处方与儿童患 ASD、无 ASD 特征的发育迟缓/障碍 (DD) 或具有自闭症特征的 ASD/DD 的风险之间的关联，这项研究是对早期发育的探索性研究，是一项神经发育的病例对照研究。与没有处方的母亲相比，围孕期开具阿片类药物处方与 ASD 的几率增加 2.43 倍[95%置信区间 (CI) 0.99, 6.02]，与具有自闭症特征的 ASD/DD 的几率增加 2.64 倍 (95% CI 1.10, 6.31)。与处方相比，孕早期开具处方的 ASD 和 ASD/DD 的几率升高，但无统计学意义。需要开展探索围孕期使用阿片类药物与儿童神经发育之间的机制和时间关系的相关工作。
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本文引用的文献
1
Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes: Executive Summary of a Joint Workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation.孕期阿片类药物使用、新生儿戒断综合征及儿童期结局：尤妮斯·肯尼迪·施莱佛国家儿童健康与人类发展研究所、美国妇产科医师学会、美国儿科学会、母胎医学协会、疾病控制与预防中心以及美国疾病防控中心和“美邦”基金会联合研讨会执行摘要
Obstet Gynecol. 2017 Jul;130(1):10-28. doi: 10.1097/AOG.0000000000002054.
2
Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.孕期母亲使用阿片类药物与先天性畸形：一项系统综述
Pediatrics. 2017 Jun;139(6). doi: 10.1542/peds.2016-4131.
3
Secular trends in opioid prescribing in the USA.美国阿片类药物处方的长期趋势。
J Pain Res. 2017 Feb 14;10:383-387. doi: 10.2147/JPR.S129553. eCollection 2017.
4
The Changing Epidemiology of Autism Spectrum Disorders.自闭症谱系障碍不断变化的流行病学特征。
Annu Rev Public Health. 2017 Mar 20;38:81-102. doi: 10.1146/annurev-publhealth-031816-044318. Epub 2016 Dec 21.
5
Demographic profile of families and children in the Study to Explore Early Development (SEED): Case-control study of autism spectrum disorder.探索早期发育研究（SEED）中家庭与儿童的人口统计学特征：自闭症谱系障碍的病例对照研究
Disabil Health J. 2016 Jul;9(3):544-51. doi: 10.1016/j.dhjo.2016.01.005. Epub 2016 Jan 29.
6
Evaluation of the relationship between opioid exposure in extremely low birth weight infants in the neonatal intensive care unit and neurodevelopmental outcome at 2 years.评估新生儿重症监护病房中极低出生体重儿的阿片类药物暴露与2岁时神经发育结局之间的关系。
Early Hum Dev. 2016 Jan;92:29-32. doi: 10.1016/j.earlhumdev.2015.11.001. Epub 2015 Nov 26.
7
Birth and Neonatal Outcomes Following Opioid Use in Pregnancy: A Danish Population-Based Study.孕期使用阿片类药物后的出生及新生儿结局：一项基于丹麦人群的研究。
Subst Abuse. 2015 Oct 9;9(Suppl 2):5-11. doi: 10.4137/SART.S23547. eCollection 2015.
8
From the genetic architecture to synaptic plasticity in autism spectrum disorder.从自闭症谱系障碍的遗传结构到突触可塑性。
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9
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Eur J Pediatr. 2015 Nov;174(11):1525-33. doi: 10.1007/s00431-015-2562-0. Epub 2015 May 24.
10
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