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[巴戟天及其盐制品对阳虚大鼠能量代谢的影响]

[Effect of Morinda officinalis Root and Its Salt-Processing Product on Energy Metabolism in Rats with Yang Deficiency].

作者信息

Huang Yu-qiu, Fan Ya-nan, Jia Tian-zhu, Geng Tong-tong, Shi Ji

出版信息

Zhong Yao Cai. 2016 May;39(5):1028-31.

Abstract

OBJECTIVE

To compare the effects of Morinda officinalis root and its salt-processing prodduct on rats with kidney yang deficiency from the viewpoint of energetic metabolism.

METHODS

The rat models for the kidney yang deficiency were established through the perfusion of methimazole. The models were treated with different dosages of Morinda officinalis root without woods and its salt-processing products extracts. The activity of liver glycogen,muscle glycogen,free fatty acid( NEFA),lipoprotein lipase( LPL),hepatic lipase( HL),liver and skeletal muscle Na+,K+ATPase,Ca2 +,Mg2 +ATPase,succinodehydrogenase( SDH) were measured by colormetric methods,and the coefficient of body fat were observed by weighing method.

RESULTS

Morinda officinalis root without woods and its saltprocessing products could improve the energetic metabolism of kidney yang deficiency of rats. The effects of salt-processing products were better than Morinda officinalis root without woods in the same dosage.

CONCLUSION

The effect of invigorating the kidney and strengthening yang of Morinda officinalis were correlated with energetic metabolism. The correct processing-products of Morinda officinalis root should be chosen with the suitable measurements in clinic.

摘要

目的

从能量代谢角度比较巴戟天及其盐制品对肾阳虚大鼠的影响。

方法

通过灌胃甲巯咪唑建立肾阳虚大鼠模型,用不同剂量的巴戟天去木根及其盐制品提取物对模型进行处理。采用比色法测定肝糖原、肌糖原、游离脂肪酸(NEFA)、脂蛋白脂肪酶(LPL)、肝脂肪酶(HL)、肝脏和骨骼肌钠钾ATP酶、钙镁ATP酶、琥珀酸脱氢酶(SDH)的活性,用称重法观察体脂系数。

结果

巴戟天去木根及其盐制品能改善肾阳虚大鼠的能量代谢。相同剂量下,盐制品的效果优于巴戟天去木根。

结论

巴戟天补肾壮阳作用与能量代谢相关。临床应选用正确炮制的巴戟天制品并采用合适的剂量。

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