拓扑和连接数控制的单链 DNA 三链闭环的合成。
Topology- and linking number-controlled synthesis of a closed 3 link chain of single-stranded DNA.
机构信息
College of Food Science and Engineering, Ocean University of China, Nucleic Acids Chemistry and Biotechnology Laboratory, No. 5 Yushan Road, Shinan-qu, Qingdao 266003, China.
出版信息
Chem Commun (Camb). 2018 Sep 6;54(72):10156-10159. doi: 10.1039/c8cc04965c.
PMID:30132764
Abstract
In spite of remarkable progress in synthetic methodology, a closed three-link chain (one of the simplest but the most important topological isomers of [3]catenane) has never been prepared. Here we synthesized this isomer in high yield from three oligonucleotides which are designed to optimize various chemical and steric factors in their mutual hybridization.
摘要
尽管在合成方法学方面取得了显著进展，但从未制备出过封闭的三链链（[3]索烃的最简单但最重要的拓扑异构体之一）。在这里，我们从三个寡核苷酸中以高产率合成了这种异构体，这些寡核苷酸的设计旨在优化它们相互杂交中的各种化学和空间因素。
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