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尿酸与组织修复

URIC ACID AND TISSUE REPAIR.

作者信息

Nery Rodrigo Araldi, Kahlow Barbara Stadler, Skare Thelma L, Tabushi Fernando Issamu, do Amaral e Castro Adham

机构信息

Evangelic Faculty of Paraná, University Evangelic Hospital of Curitiba, Curitiba, PR, Brazil.

出版信息

Arq Bras Cir Dig. 2015 Nov-Dec;28(4):290-2. doi: 10.1590/S0102-6720201500040018.

DOI:10.1590/S0102-6720201500040018
PMID:26734804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4755186/
Abstract

Uric acid, a metabolic product of purines, may exert a role in tissue healing. In this review we will explore its role as an alarm initiating the inflammatory process that is necessary for tissue repair, as a scavenger of oxygen free radicals, as a mobilizer of progenitor endothelial cells and as supporter of adaptive immune system.

摘要

尿酸作为嘌呤的代谢产物，可能在组织愈合中发挥作用。在本综述中，我们将探讨其作为启动组织修复所需炎症过程的警报信号、作为氧自由基清除剂、作为祖内皮细胞动员剂以及作为适应性免疫系统支持者的作用。

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URIC ACID AND TISSUE REPAIR.尿酸与组织修复
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[Uric acid as a scavenger in oxidative stress].[尿酸作为氧化应激中的一种清除剂]
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本文引用的文献

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Effect of platelet-rich plasma on the healing of cutaneous defects exposed to acute to chronic wounds: a clinico-histopathologic study in rabbits.富血小板血浆对急性至慢性伤口皮肤缺损愈合的影响：一项兔的临床组织病理学研究
Diagn Pathol. 2015 Jul 2;10:85. doi: 10.1186/s13000-015-0327-8.
2
Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.在一大群胰腺癌患者中评估尿酸作为一种基于血液的预后标志物。
PLoS One. 2014 Aug 18;9(8):e104730. doi: 10.1371/journal.pone.0104730. eCollection 2014.
3
Serum uric acid levels and cancer mortality risk among males in a large general population-based cohort study.一项基于大规模普通人群的队列研究中男性血清尿酸水平与癌症死亡风险
Cancer Causes Control. 2014 Aug;25(8):1075-80. doi: 10.1007/s10552-014-0408-0. Epub 2014 Jun 7.
4
Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects.肥胖人群血浆尿酸对其抗氧化能力、氧化应激及胰岛素敏感性的影响。
Diabetes. 2014 Mar;63(3):976-81. doi: 10.2337/db13-1396. Epub 2013 Dec 18.
5
8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients.8-氧代-7,8-二氢鸟嘌呤和尿酸作为结直肠癌患者生存的有效预测因子。
Int J Cancer. 2014 Jan 15;134(2):376-83. doi: 10.1002/ijc.28374. Epub 2013 Aug 5.
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Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.针对肿瘤相关抗原的中枢和效应记忆性CD4和CD8 T细胞反应。
Crit Rev Immunol. 2012;32(2):97-126. doi: 10.1615/critrevimmunol.v32.i2.10.
7
Uric acid and cardiovascular risk in rheumatoid arthritis.类风湿关节炎中的尿酸与心血管风险
Rheumatology (Oxford). 2011 Aug;50(8):1354-5. doi: 10.1093/rheumatology/keq388. Epub 2010 Nov 28.
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A synthetic uric acid analog accelerates cutaneous wound healing in mice.一种合成尿酸类似物可加速小鼠皮肤伤口愈合。
PLoS One. 2010 Apr 6;5(4):e10044. doi: 10.1371/journal.pone.0010044.
9
Uric acid and cardiovascular risk.尿酸与心血管风险。
N Engl J Med. 2008 Oct 23;359(17):1811-21. doi: 10.1056/NEJMra0800885.
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Association of serum uric acid with cardiovascular disease in rheumatoid arthritis.类风湿关节炎患者血清尿酸与心血管疾病的关联
Rheumatology (Oxford). 2007 Sep;46(9):1466-70. doi: 10.1093/rheumatology/kem159. Epub 2007 Jul 21.