Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Department of Biomedical Engineering, National University of Singapore.
J Glaucoma. 2018 Nov;27(11):1009-1016. doi: 10.1097/IJG.0000000000001062.
The aim of this study was to compare the peripapillary vessel density between eyes with pseudoexfoliation glaucoma (PXG) and eyes with primary open-angle glaucoma (POAG).
Peripapillary vessel density in the radial peripapillary capillaries was assessed using optical coherence tomography angiography, and compared between patients with PXG and those with POAG, matched for age and mean deviation (MD) of standard automated perimetry. The vessel density was measured between the optic disc margin and 750 μm from the optic disc margin.
In total, 39 eyes with PXG were matched to 39 eyes with POAG. Mean untreated intraocular pressure was higher in the PXG group than in the POAG group (21.4±6.7 vs. 14.9±2.9 mm Hg; P<0.001), but there was no difference in age, refractive error, visual field MD, or average retinal nerve fiber layer thickness between the 2 groups. However, the average peripapillary vessel density in the radial peripapillary capillaries was lower in the eyes with PXG than in the eyes with POAG. Moreover, there was a significant correlation between peripapillary vessel density and both visual field MD and retinal nerve fiber layer thickness.
Peripapillary vessel density was lower in eyes with PXG than in eyes with POAG of similar severity.
本研究旨在比较假性剥脱性青光眼（PXG）和原发性开角型青光眼（POAG）患者的视盘周围血管密度。
采用光相干断层扫描血管造影术评估视盘周围毛细血管的视盘周围血管密度，并与年龄和标准自动视野计平均偏差（MD）相匹配的 PXG 和 POAG 患者进行比较。血管密度在视盘边缘和视盘边缘 750μm 之间进行测量。
共匹配了 39 只 PXG 眼和 39 只 POAG 眼。未经治疗的眼内压在 PXG 组中高于 POAG 组（21.4±6.7 比 14.9±2.9mmHg；P<0.001），但两组之间的年龄、屈光不正、视野 MD 或平均视网膜神经纤维层厚度无差异。然而，PXG 眼中的视盘周围毛细血管的平均视盘周围血管密度低于 POAG 眼中。此外，视盘周围血管密度与视野 MD 和视网膜神经纤维层厚度均有显著相关性。
与严重程度相似的 POAG 眼相比，PXG 眼的视盘周围血管密度较低。
