Kim Ji Eun, Oh Eungseok, Park Jinse, Youn Jinyoung, Kim Ji Sun, Jang Wooyoung
Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.
Department of Neurology, Chungnam National University, College of Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
J Clin Neurosci. 2018 Nov;57:131-135. doi: 10.1016/j.jocn.2018.08.003. Epub 2018 Aug 19.
The purpose of our study was to investigate the association between olfactory function in Parkinson's disease (PD) and serum vitamin D status. Thirty-nine patients with de novo PD were enrolled in this study. Olfactory function was assessed by an odor identification test, as a part of the KVSS (Korean version of sniffin' sticks) II test. All patients were also assessed with the NMSS (Non-Motor Symptoms Scale for PD) to check the subjective change in ability to smell. Vitamin D status was determined by measuring the level of serum 25-hydroxyvitamin D3 (25-OHD3). Multiple linear regression tests and correlation analysis were applied to verify the association between serum 25-OHD3 level and patients' subjective and objective olfactory dysfunction. The serum 25-OHD3 level was independently associated with odor identification score in patients with PD (β = 0.38, p < 0.01). Another statistically significant variable was clinical subtype of PD (Intermediate subtype: β = -0.33, p < 0.05; Akinetic rigid type: β = -0.55, p < 0.01). The serum 25-OHD3 level was also negatively correlated with the score for item number 28 in NMSS (Spearman's rho = -0.32, p < 0.05). Our results showed that vitamin D status might be an independent factor for olfactory dysfunction in PD. Although the underlying mechanism has not been clearly identified, we postulate that vitamin D plays a role in the pathogenesis of olfactory dysfunction in PD. Further investigation to elucidate the precise relationship of vitamin D to PD is essential.
我们研究的目的是调查帕金森病（PD）患者的嗅觉功能与血清维生素D水平之间的关联。本研究纳入了39例初发PD患者。嗅觉功能通过气味识别测试进行评估，该测试是韩国版嗅觉棒（KVSS）II测试的一部分。所有患者还接受了非运动症状量表（NMSS）评估，以检查嗅觉能力的主观变化。通过测量血清25-羟维生素D3（25-OHD3）水平来确定维生素D状态。应用多元线性回归测试和相关性分析来验证血清25-OHD3水平与患者主观和客观嗅觉功能障碍之间的关联。血清25-OHD3水平与PD患者的气味识别得分独立相关（β = 0.38，p < 0.01）。另一个具有统计学意义的变量是PD的临床亚型（中间亚型：β = -0.33，p < 0.05；运动迟缓僵硬型：β = -0.55，p < 0.01）。血清25-OHD3水平也与NMSS中第28项的得分呈负相关（Spearman等级相关系数ρ = -0.32，p < 0.05）。我们的结果表明，维生素D状态可能是PD患者嗅觉功能障碍的一个独立因素。尽管潜在机制尚未明确，但我们推测维生素D在PD嗅觉功能障碍的发病机制中起作用。进一步研究以阐明维生素D与PD的确切关系至关重要。
