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1976 年至 2018 年:对早期埃博拉病毒研究的反思。

From 1976 to 2018: reflections on early investigations into the Ebola virus.

机构信息

London School of Hygiene & Tropical Medicine, Keppel St, London, UK.

出版信息

Trans R Soc Trop Med Hyg. 2018 Dec 1;112(12):527-528. doi: 10.1093/trstmh/try088.

DOI:10.1093/trstmh/try088
PMID:30137538
Abstract

In the late 1970s, early investigations into the Ebola virus informed the world's understanding of what was then an unknown disease. One such study, published by Bowen and colleagues in 1978, laid the foundations for future research into its prevention and treatment. However, nearly four decades later, scientific progress had not translated into action on the ground with no approved drugs, no vaccines, and no diagnostic tests available when the 2014-15 outbreak began in West Africa. Encouragingly, it appears that we have learned important lessons from the 2014-2015 outbreak, with a swift and rigorous response to the most recent outbreaks in Équateur Province, Democratic Republic of Congo, including the deployment of a vaccine. Ebola will certainly remain a challenge in the years to come and we as the global health community must ensure that innovative research translates into policy and action on the ground, with the full participation of affected communities.

摘要

在 20 世纪 70 年代末,对埃博拉病毒的早期调查使世界了解了这种当时未知的疾病。其中一项由 Bowen 及其同事于 1978 年发表的研究为后来对其预防和治疗的研究奠定了基础。然而,近四十年后,科学进展并没有转化为实际行动,当 2014-2015 年西非暴发疫情时,没有批准的药物、疫苗和诊断检测方法。令人鼓舞的是,我们似乎从 2014-2015 年的疫情中吸取了重要教训,对刚果民主共和国赤道省最近的疫情迅速采取了严格的应对措施,包括部署疫苗。埃博拉病毒在未来几年肯定仍然是一个挑战,我们全球卫生界必须确保创新研究转化为政策和实地行动,同时充分让受影响社区参与进来。

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