Affinity chromatographic analysis of murine interferons induced by viruses and by T and B cell stimulants.

Murine interferons induced by viruses and by non-viral substances such as lectins, tilorone, lipopolysaccharide and Brucella have been analysed by affinity chromatography on a column of Sepharose coupled to antiviral interferon antibodies. The results reported here suggest that virus and B-cell stimulants induced interferons which are antigenically related and that T cell-dependent mitogens induce and "interferon like" molecule which appears to be antigenically and physiocochemically different.