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本文引用的文献

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Global epidemiology and burden of HCV infection and HCV-related disease.全球丙型肝炎病毒感染及相关疾病的流行病学和负担。
Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):122-132. doi: 10.1038/nrgastro.2016.176. Epub 2016 Dec 7.
2
The impact of chronic hepatitis C infection on cholesterol metabolism in PBMCs is associated with microRNA-146a expression.慢性丙型肝炎感染对PBMCs中胆固醇代谢的影响与微小RNA-146a的表达有关。
Eur J Clin Microbiol Infect Dis. 2017 Apr;36(4):697-702. doi: 10.1007/s10096-016-2851-1. Epub 2016 Nov 25.
3
Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation.脂蛋白脂肪酶释放游离脂肪酸以抑制丙型肝炎病毒感染并防止肝脏脂质积累。
Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12673. Epub 2016 Nov 25.
4
Hepatitis C virus life cycle and lipid metabolism.丙型肝炎病毒的生命周期与脂质代谢。
Biology (Basel). 2014 Dec 15;3(4):892-921. doi: 10.3390/biology3040892.
5
miR-122--a key factor and therapeutic target in liver disease.miR-122——肝病的关键因子和治疗靶点。
J Hepatol. 2015 Feb;62(2):448-57. doi: 10.1016/j.jhep.2014.10.004. Epub 2014 Oct 13.
6
Decreased level of intracellular cholesterol in peripheral blood mononuclear cells is associated with chronic hepatitis C virus infection.外周血单个核细胞内胆固醇水平降低与慢性丙型肝炎病毒感染有关。
Virus Res. 2013 Dec 26;178(2):539-42. doi: 10.1016/j.virusres.2013.09.019. Epub 2013 Sep 18.
7
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.丙型肝炎病毒、胆固醇和脂蛋白——对病毒生命周期和肝病发病机制的影响。
Viruses. 2013 May 23;5(5):1292-324. doi: 10.3390/v5051292.
8
Lipoprotein component associated with hepatitis C virus is essential for virus infectivity.与丙型肝炎病毒相关的脂蛋白成分是病毒感染力所必需的。
Curr Opin Virol. 2011 Jul;1(1):19-26. doi: 10.1016/j.coviro.2011.05.017. Epub 2011 Jun 12.
9
Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry.脂蛋白脂肪酶通过阻止病毒进入细胞来抑制丙型肝炎病毒 (HCV) 感染。
PLoS One. 2011;6(10):e26637. doi: 10.1371/journal.pone.0026637. Epub 2011 Oct 21.
10
Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins.载脂蛋白脂肪酶和肝脂肪酶通过对 HCV 相关脂蛋白的催化作用降低丙型肝炎病毒 (HCV) 的感染力。
Virology. 2010 Nov 10;407(1):152-9. doi: 10.1016/j.virol.2010.08.011. Epub 2010 Sep 6.

慢性丙型肝炎患者 miR-122 与脂蛋白脂肪酶表达的相关性。

The Correlation between miR-122 and Lipoprotein Lipase Expression in Chronic Hepatitis C Patients.

机构信息

Medical University of Lodz, Poland.

出版信息

Can J Gastroenterol Hepatol. 2018 Jul 24;2018:6348948. doi: 10.1155/2018/6348948. eCollection 2018.

DOI:10.1155/2018/6348948
PMID:30140663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6081532/
Abstract

Chronic HCV infection is strictly associated with host lipid/lipoprotein metabolism disorders. The study aimed to analyze the relationship between viral load, lipid profile, IFN, and the expression of miR-122 and LPL in the liver and PBMCs. Sera, PBMCs, and matching liver biopsies from 17 chronic hepatitis C patients were enrolled in this study. Collected data shows that liver (not PBMCs) miR-122 expression is positively correlated with HCV RNA load and IFN and reversely with LPL expression in CHC patients. Presented, for the first time, in this study, the reverse correlation of miR-122 and LPL expression in liver; miR-122 and LPL seem to be important factors of CHC infection.

摘要

慢性 HCV 感染与宿主脂质/脂蛋白代谢紊乱密切相关。本研究旨在分析病毒载量、血脂谱、IFN 以及 miR-122 和 LPL 在肝和 PBMCs 中的表达之间的关系。本研究纳入了 17 例慢性丙型肝炎患者的血清、PBMCs 和匹配的肝活检组织。结果表明，慢性丙型肝炎患者肝（而非 PBMCs）中 miR-122 的表达与 HCV RNA 载量和 IFN 呈正相关，与 LPL 表达呈负相关。本研究首次发现，miR-122 和 LPL 在肝组织中的表达呈负相关；miR-122 和 LPL 似乎是 CHC 感染的重要因素。