Murph J R, Bale J F, Murray J C, Stinski M F, Perlman S
J Pediatr. 1986 Jul;109(1):35-9. doi: 10.1016/s0022-3476(86)80568-6.
The epidemiology of cytomegalovirus (CMV) infection and transmission in a large Iowa day care center was studied. Over the 9 months of the study the overall CMV prevalence rates were 21% to 22%, with rates as high as 71% in toddlers. Titers of CMV in the urine or saliva of infected children were as high as 3 X 10(4) plaque-forming units of CMV per milliliter, similar to titers of CMV observed in some congenitally infected infants. Restriction enzyme analysis of CMV isolates from children in the center demonstrated two major clusters with similar patterns, one among 2- and 3-year-old children and another among infants. The clustering of similar CMV isolates among nonambulatory infants suggests that child care or hygienic practices may contribute to the spread of CMV infection in day care centers. Furthermore, the relatively high prevalence of CMV excretion in this center and the low seropositivity rates to CMV among adults in Iowa suggest that adults in the Midwest who have contact with children in day care centers may be at risk for primary CMV infection.
对爱荷华州一家大型日托中心的巨细胞病毒（CMV）感染和传播的流行病学情况进行了研究。在为期9个月的研究中，CMV总体患病率为21%至22%，幼儿中的患病率高达71%。受感染儿童尿液或唾液中的CMV滴度高达每毫升3×10⁴个CMV空斑形成单位，这与在一些先天性感染婴儿中观察到的CMV滴度相似。对该中心儿童的CMV分离株进行的限制性内切酶分析显示，有两个主要的聚类，其模式相似，一个在2至3岁儿童中，另一个在婴儿中。不会行走的婴儿中相似CMV分离株的聚类表明，儿童护理或卫生习惯可能会导致CMV感染在日托中心传播。此外，该中心CMV排泄的相对高患病率以及爱荷华州成年人中CMV血清阳性率较低表明，在中西部与日托中心儿童有接触的成年人可能有原发性CMV感染的风险。
