Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers , Fudan University , Shanghai 200433 , People's Republic of China.
ACS Appl Mater Interfaces. 2018 Sep 19;10(37):31664-31673. doi: 10.1021/acsami.8b11825. Epub 2018 Sep 6.
Dual-porosity hollow carbon spheres (DPHCs) with small mesopores (2-4 nm) and large through-holes (20-30 nm) in shells were successfully synthesized using colloidal silica as the template, small silica nanoparticles as nanomasks, and nontoxic dopamine as the carbon precursor followed by post-carbonization and etching. The synthesized DPHCs were further oxidized to be hydrophilic and then used to simultaneously deliver the protein bovine serum albumin (21 × 4 × 14 nm) and the small molecule doxorubicin (<1 nm), which exhibited a high loading capacity of 689.4 and 1421.2 mg/g, respectively. The release of these two guest molecules can be controlled independently under the stimuli of heat and acidity. In vitro and in vivo experiments also proved that the DPHCs are promising for the co-delivery of multiple cargoes of different sizes.
具有小介孔（2-4nm）和壳中大贯穿孔（20-30nm）的双孔中空碳球（DPHCs），是采用胶体硅作为模板、小硅纳米颗粒作为纳米掩模以及无毒多巴胺作为碳前驱体，然后经过碳化和刻蚀反应成功合成的。所合成的 DPHCs 进一步氧化为亲水性，然后用于同时递送蛋白质牛血清白蛋白（21×4×14nm）和小分子阿霉素（<1nm），其载药量分别高达 689.4 和 1421.2mg/g。在热和酸度刺激下，可以分别对这两种客体分子的释放进行独立控制。体外和体内实验也证明，DPHCs 非常适合于不同大小的多种载药的共递送。
