Nyírő Gyula National Institute of Psychiatry and Addictions, Budapest, Hungary.
Nyírő Gyula National Institute of Psychiatry and Addictions, Budapest, Hungary; Department of Cognitive Science, Budapest University of Technology and Economics, Budapest, Hungary; Department of Physiology, University of Szeged, Faculty of Medicine, Szeged, Hungary.
J Affect Disord. 2018 Dec 1;241:305-310. doi: 10.1016/j.jad.2018.08.021. Epub 2018 Aug 8.
Evidence suggests that microglia-mediated processes are implicated in the pathophysiology of major depressive disorder (MDD). The relationship between these processes and cognitive dysfunctions has not been explored.
We recruited 50 never-medicated patients with MDD and 30 healthy control subjects. We used [F]-FEPPA positron emission tomography (PET) to examine translocator protein total distribution volume (TSPO V), a marker of microglia. Cognitive functions were evaluated with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) (attention, immediate and delyed memory, language, and visuospatial functions).
Patients with MDD showed elevated TSPO V in all regions of interest (white matter, grey matter, frontal cortex, temporal cortex, and hippocampus) and were impaired on the attention and delayed memory domains of the RBANS. In the frontal cortex, increased TSPO V was associated with lower scores on the RBANS attention domain when the analysis was corrected for age, gender, education, and depressive symptoms.
Affective functions were not investigated, the specificity of [F]-FEPPA binding is limited, TSPO may reflect microglia/macrophage density rather than activation, and the sample was not balanced (more patients were included than controls).
Attentional dysfunctions may be associated with microglial pathology in the frontal cortex of untreated patients with MDD.
有证据表明，小胶质细胞介导的过程与重度抑郁症（MDD）的病理生理学有关。这些过程与认知功能障碍之间的关系尚未得到探索。
我们招募了 50 名从未接受过治疗的 MDD 患者和 30 名健康对照者。我们使用 [F]-FEPPA 正电子发射断层扫描（PET）来检查转位蛋白总分布容积（TSPO V），这是小胶质细胞的标志物。认知功能通过重复神经心理状态评估电池（RBANS）进行评估（注意力、即刻和延迟记忆、语言和视觉空间功能）。
MDD 患者在所有感兴趣的区域（白质、灰质、额叶皮层、颞叶皮层和海马体）中均显示出 TSPO V 升高，并且在 RBANS 的注意力和延迟记忆域中受损。在额叶皮层中，当分析针对年龄、性别、教育程度和抑郁症状进行校正时，TSPO V 的增加与 RBANS 注意力域的得分较低相关。
未研究情感功能，[F]-FEPPA 结合的特异性有限，TSPO 可能反映小胶质细胞/巨噬细胞密度而不是激活，并且样本不平衡（患者比对照者多）。
注意力功能障碍可能与未经治疗的 MDD 患者额叶皮层中的小胶质细胞病理学有关。
