Unidad de Terapia Celular y Medicina Regenerativa, Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
Plataforma de Terapias Avanzadas, Instituto de Investigación Biosanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Biotechnol Bioeng. 2018 Dec;115(12):3009-3029. doi: 10.1002/bit.26821. Epub 2018 Sep 25.
Pancreatic islet transplantation is a promising alternative to whole-pancreas transplantation as a treatment of type 1 diabetes mellitus. This technique has been extensively developed during the past few years, with the main purpose of minimizing the complications arising from the standard protocols used in organ transplantation. By using a variety of strategies used in tissue engineering and regenerative medicine, pancreatic islets have been successfully introduced in host patients with different outcomes in terms of islet survival and functionality, as well as the desired normoglycemic control. Here, we describe and discuss those strategies to transplant islets together with different scaffolds, in combination with various cell types and diffusible factors, and always with the aim of reducing host immune response and achieving islet survival, regardless of the site of transplantation.
胰岛移植作为治疗 1 型糖尿病的一种有前途的方法，可替代全胰移植。在过去的几年中，该技术得到了广泛的发展，其主要目的是最大限度地减少器官移植中标准方案引起的并发症。通过使用组织工程和再生医学中使用的各种策略，已经成功地将胰岛引入宿主患者中，在胰岛存活和功能方面以及所需的正常血糖控制方面具有不同的结果。在这里，我们描述并讨论了这些策略，包括将胰岛与不同的支架一起移植，结合各种细胞类型和可扩散因子，并且始终旨在减轻宿主免疫反应并实现胰岛存活，而不管移植部位如何。
