Delespesse G, De Maubeuge J, Kennes B, Nicaise R, Govaerts A
Clin Allergy. 1977 Mar;7(2):155-60. doi: 10.1111/j.1365-2222.1977.tb01436.x.
The serum IgE concentration is significantly lower in aged as compared with young people. This is more pronounced in males than in females (P less than 0-05). In fifteen aged (greater than 70 years) compared with fifteen young subjects (less than 40) the specific IgE antibody response to an injection of diphtheria toxoid was significantly reduced (P less than 0-01). The minimum concentration of anti-IgE antibody able to induce a weal and flare reaction when injected intradermally, was comparable in the two age groups. However, the diameter of the weal reaction was significantly reduced in the aged. It is concluded that the reduced incidence of atopic symptoms in old people might be secondary to an anomaly of both the immune system and the mast cells.
与年轻人相比，老年人血清IgE浓度显著降低。男性比女性更明显（P小于0.05）。与15名年轻受试者（小于40岁）相比，15名老年人（大于70岁）对白喉类毒素注射的特异性IgE抗体反应显著降低（P小于0.01）。两组皮内注射能引起风团和潮红反应的抗IgE抗体的最低浓度相当。然而，老年人风团反应的直径显著减小。得出的结论是，老年人特应性症状发生率降低可能继发于免疫系统和肥大细胞的异常。
