Gajęcka Magdalena, Waśkiewicz Agnieszka, Zielonka Łukasz, Goliński Piotr, Rykaczewska Anna, Lisieska-Żołnierczyk Sylwia, Gajęcki Maciej T
Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718, Olsztyn, Poland.
Department of Chemistry, Poznań University of Life Sciences, Wojska Polskiego 75, 60-625, Poznań, Poland.
Toxicon. 2018 Oct;153:1-11. doi: 10.1016/j.toxicon.2018.08.002. Epub 2018 Aug 23.
Most plant materials are contaminated with small doses of Fusarium mycotoxins and its modified forms that exert subclinical toxic effects on humans and animals. The aim of this study was to evaluate the carry-over of zearalenone and deoxynivalenol (pure parent compounds) to intestinal and liver tissues during 6 weeks of exposure to mycotoxins administered per os to gilts. The experiment was performed on 36 gilts with average body weight of 25 ± 2 kg, divided into 2 groups: an experimental group (group E, administered zearalenone at 40 μg/kg BW and deoxynivalenol at 12 μg/kg BW daily with feed) and a control group administered placebo. Tissue saturation with mycotoxins was analysed by liquid chromatography in samples collected at weekly intervals. Six gilts were euthanized in each week of the study. The conducted analyses revealed: (i) a non-uniform increase in zearalenone levels in the duodenum, jejunum, ascending colon and the liver; and (ii) an increase in deoxynivalenol levels, mainly in the ileum, caecum, ascending colon and the transverse colon, and a minor increase in the liver. The degree of tissue saturation was determined by the type of mycotoxin, but not by the time of exposure.
大多数植物材料都被小剂量的镰刀菌霉菌毒素及其修饰形式污染，这些毒素会对人和动物产生亚临床毒性作用。本研究的目的是评估在给后备母猪经口投喂霉菌毒素6周期间，玉米赤霉烯酮和脱氧雪腐镰刀菌烯醇（纯母体化合物）在肠道和肝脏组织中的残留情况。实验选用36头平均体重为25±2 kg的后备母猪，分为2组：实验组（E组，每天通过饲料给予40 μg/kg体重的玉米赤霉烯酮和12 μg/kg体重的脱氧雪腐镰刀菌烯醇）和给予安慰剂的对照组。每周采集样本，通过液相色谱分析组织中霉菌毒素的饱和度。在研究的每周对6头后备母猪实施安乐死。进行的分析显示：（i）十二指肠、空肠、升结肠和肝脏中玉米赤霉烯酮水平呈不均匀增加；（ii）脱氧雪腐镰刀菌烯醇水平增加，主要在回肠、盲肠、升结肠和横结肠，肝脏中也有少量增加。组织饱和程度取决于霉菌毒素的类型，而非暴露时间。
