从“奇楠”沉香内生真菌尖孢镰刀菌 HP-2 中分离得到的新次生代谢产物。
New secondary metabolites from the endophytic fungus Fusarium sp. HP-2 isolated from "Qi-Nan" agarwood.
机构信息
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
出版信息
Fitoterapia. 2018 Oct;130:180-183. doi: 10.1016/j.fitote.2018.08.008. Epub 2018 Aug 24.
A novel pyrone derivative (1) bearing two fused five-member rings, together with two new naphthalenone derivatives (2, 3), as well as two known compounds (4, 5) were obtained from the endophytic fungus Fusarium sp. HP-2, which was isolated from "Qi-Nan" agarwood. The structures of the new compounds were elucidated by analysis of 1D and 2D NMR, and by HRESIMS spectra, as well as by comparison with the literature. Bioactivity results indicated that compound 3 showed weak acetylcholinesterase inhibitory activity.
从“奇楠”沉香内生真菌尖孢镰刀菌（Fusarium sp.）HP-2 中分离得到一个新型吡喃酮衍生物（1），它含有两个稠合的五元环，以及两个新的萘醌衍生物（2、3）和两个已知化合物（4、5）。通过一维和二维 NMR、高分辨率电喷雾质谱（HRESIMS）谱以及与文献数据的比较，解析了这些新化合物的结构。生物活性测试结果表明，化合物 3 对乙酰胆碱酯酶具有较弱的抑制活性。
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