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From human pluripotent stem cells to functional kidney organoids and models of renal disease.从人多能干细胞到功能性肾脏类器官及肾脏疾病模型。
Stem Cell Investig. 2018 Jul 21;5:20. doi: 10.21037/sci.2018.07.02. eCollection 2018.
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[Kidney organoids].[肾脏类器官]
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Generation of kidney tubular organoids from human pluripotent stem cells.从人类多能干细胞生成肾管状类器官。
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Applications of kidney organoids derived from human pluripotent stem cells.源自人类多能干细胞的肾类器官的应用。
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Stem cell-derived kidney cells and organoids: Recent breakthroughs and emerging applications.干细胞衍生的肾脏细胞和类器官：最新突破和新兴应用。
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induction and engraftment of kidney organoids derived from human pluripotent stem cells.源自人类多能干细胞的肾类器官的诱导与植入。
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Eur J Pharmacol. 2016 Nov 5;790:12-20. doi: 10.1016/j.ejphar.2016.06.059. Epub 2016 Jul 1.
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Obstacles in Renal Regenerative Medicine: Metabolic and Epigenetic Parallels Between Cellular Reprogramming and Kidney Cancer Oncogenesis.肾脏再生医学中的障碍：细胞重编程与肾癌发生之间的代谢和表观遗传平行关系。
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Unveiling spontaneous renal tubule-like structures from human adult renal progenitor cell spheroids derived from urine.从尿液来源的成人肾祖细胞球体中揭示自发形成的肾小管样结构。
Stem Cells Transl Med. 2025 Mar 18;14(3). doi: 10.1093/stcltm/szaf002.
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Aberrant Differentiation of Human Pluripotent Stem Cell-Derived Kidney Precursor Cells inside Mouse Vascularized Bioreactors.人多能干细胞衍生的肾前体细胞在血管化生物反应器内的异常分化。
Nephron. 2020;144(10):509-524. doi: 10.1159/000509425. Epub 2020 Aug 5.
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Growing a new human kidney.培育人类新肾脏。
Kidney Int. 2019 Oct;96(4):871-882. doi: 10.1016/j.kint.2019.04.040. Epub 2019 May 25.
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MAPK/ERK Signaling in Regulation of Renal Differentiation.MAPK/ERK 信号通路在肾脏分化中的调控作用。
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The myriad possibility of kidney organoids.类器官肾脏的万千可能。
Curr Opin Nephrol Hypertens. 2019 May;28(3):211-218. doi: 10.1097/MNH.0000000000000498.

本文引用的文献

1
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.患者诱导多能干细胞衍生的肾类器官显示出对纤毛病肾脏表型的功能验证，并揭示了潜在的发病机制。
Am J Hum Genet. 2018 May 3;102(5):816-831. doi: 10.1016/j.ajhg.2018.03.014. Epub 2018 Apr 26.
2
Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo.PSC 来源的肾类器官肾被膜下移植诱导体内新生血管生成和显著的肾小球和肾小管成熟。
Stem Cell Reports. 2018 Mar 13;10(3):751-765. doi: 10.1016/j.stemcr.2018.01.041. Epub 2018 Mar 1.
3
Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning.人类和小鼠肾单位发生的保守和分歧的分子及解剖学特征。
J Am Soc Nephrol. 2018 Mar;29(3):825-840. doi: 10.1681/ASN.2017091036. Epub 2018 Feb 15.
4
Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.人肾和鼠肾皮质肾发生龛中间质祖细胞类型的保守和分化特征。
J Am Soc Nephrol. 2018 Mar;29(3):806-824. doi: 10.1681/ASN.2017080890. Epub 2018 Feb 15.
5
Kidney-differentiated cells derived from Lowe Syndrome patient's iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex.源自洛氏综合征患者诱导多能干细胞的肾分化细胞表现出纤毛发生缺陷以及Six2在高尔基体的滞留。
PLoS One. 2018 Feb 14;13(2):e0192635. doi: 10.1371/journal.pone.0192635. eCollection 2018.
6
Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors.人多能干细胞衍生的肾祖细胞植入后生成有功能的肾单位。
Stem Cell Reports. 2018 Mar 13;10(3):766-779. doi: 10.1016/j.stemcr.2018.01.008. Epub 2018 Feb 8.
7
HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis.肝细胞核因子1β（HNF1B）在输尿管芽分支和集合管形态发生过程中控制上皮组织和细胞极性。
Development. 2017 Dec 15;144(24):4704-4719. doi: 10.1242/dev.154336. Epub 2017 Nov 20.
8
Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.多能干细胞衍生的高级肾脏器官发生。
Cell Stem Cell. 2017 Dec 7;21(6):730-746.e6. doi: 10.1016/j.stem.2017.10.011. Epub 2017 Nov 9.
9
Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.基因编辑人类肾类器官揭示足细胞发育疾病的机制。
Stem Cells. 2017 Dec;35(12):2366-2378. doi: 10.1002/stem.2707. Epub 2017 Sep 29.
10
Development of the Mammalian Kidney.哺乳动物肾脏的发育
Curr Top Dev Biol. 2016;117:31-64. doi: 10.1016/bs.ctdb.2015.10.010. Epub 2016 Jan 23.

From human pluripotent stem cells to functional kidney organoids and models of renal disease.

作者信息

Kimber Susan J, Woolf Adrian S

机构信息

Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.

Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

出版信息

Stem Cell Investig. 2018 Jul 21;5:20. doi: 10.21037/sci.2018.07.02. eCollection 2018.

DOI:10.21037/sci.2018.07.02
PMID:30148153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6087798/
Abstract
摘要