Research Center for Electronics and Telecommunications, Indonesian Institute of Sciences, Bandung 40135, Indonesia.
Department of Electronics Engineering, Chang Gung University, Taoyuan 33302, Taiwan.
Biosensors (Basel). 2018 Aug 26;8(3):80. doi: 10.3390/bios8030080.
The notion of surface plasmon resonance (SPR) sensor research emerged more than eight decades ago from the first observed phenomena in 1902 until the first introduced principles for gas sensing and biosensing in 1983. The sensing platform has been hand-in-hand with the plethora of sensing technology advancement including nanostructuring, optical technology, fluidic technology, and light source technology, which contribute to substantial progress in SPR sensor evolution. Nevertheless, the commercial products of SPR sensors in the market still require high-cost investment, component, and operation, leading to unaffordability for their implementation in a low-cost point of care (PoC) or laboratories. In this article, we present a comprehensive review of SPR sensor development including the state of the art from a perspective of light source technology trends. Based on our review, the trend of SPR sensor configurations, as well as its methodology and optical designs are strongly influenced by the development of light source technology as a critical component. These simultaneously offer new underlying principles of SPR sensor towards miniaturization, portability, and disposability features. The low-cost solid-state light source technology, such as laser diode, light-emitting diode (LED), organic light emitting diode (OLED) and smartphone display have been reported as proof of concept for the future of low-cost SPR sensor platforms. Finally, this review provides a comprehensive overview, particularly for SPR sensor designers, including emerging engineers or experts in this field.
表面等离子体共振（SPR）传感器研究的概念早在 80 多年前就出现了，从 1902 年首次观察到现象到 1983 年首次引入气体传感和生物传感原理。传感平台与包括纳米结构、光学技术、流体技术和光源技术在内的众多传感技术进步齐头并进，这为 SPR 传感器的发展带来了实质性的进步。然而，市场上的 SPR 传感器的商业产品仍然需要高成本的投资、元件和运营，这导致其在低成本的即时护理（PoC）或实验室中无法实现。在本文中，我们从光源技术趋势的角度对 SPR 传感器的发展进行了全面的回顾。基于我们的综述，SPR 传感器配置的趋势以及其方法和光学设计都受到光源技术作为关键组件的发展的强烈影响。这些同时为 SPR 传感器的小型化、便携性和一次性功能提供了新的潜在原理。低成本的固态光源技术，如激光二极管、发光二极管（LED）、有机发光二极管（OLED）和智能手机显示屏，已经被报道为未来低成本 SPR 传感器平台的概念验证。最后，本综述为 SPR 传感器设计师，包括该领域的新兴工程师或专家，提供了全面的概述。
