Zhang Lizhong, He Mingyi, Xu Yang, Guo Cuixia, Zhou Chongqi, Guan Tian
Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
School of International Education, Beijing University of Chemical Technology, Beijing, China.
Front Chem. 2024 Mar 8;12:1382251. doi: 10.3389/fchem.2024.1382251. eCollection 2024.
An ultra-sensitive phase plasmonic sensor combined with weak value amplification is proposed for the detection of IgG, as a model analyte. Phase detection is accomplished by self-interference between the p-polarization and the s-polarization of the light. With the principles of weak value amplification, a phase compensator is used to modulate the coupling strength and enhance the refractive index sensitivity of the system. On a simple Au-coated prism-coupled surface plasmon resonance (SPR) structure, the scheme, called WMSPR, achieves a refractive index sensitivity of 4.737 × 10 nm/RIU, which is about three times higher than that of the conventional phase-based approach. The proposed WMSPR biosensor gives great characteristics with a high resolution of 6.333 × 10 RIU and a low limit of detection (LOD) of 5.3 ng/mL. The results yield a great scope to promote the optimization of other SPR biosensors for high sensitivity.
本文提出了一种结合弱值放大的超灵敏相位等离子体传感器，用于检测作为模型分析物的IgG。相位检测是通过光的p偏振和s偏振之间的自干涉来完成的。基于弱值放大原理，使用相位补偿器来调制耦合强度并提高系统的折射率灵敏度。在一个简单的镀金光棱镜耦合表面等离子体共振（SPR）结构上，这种称为WMSPR的方案实现了4.737×10 nm/RIU的折射率灵敏度，约为传统基于相位方法的三倍。所提出的WMSPR生物传感器具有6.333×10 RIU的高分辨率和5.3 ng/mL的低检测限等优异特性。这些结果为促进其他SPR生物传感器的高灵敏度优化提供了广阔空间。
