多发性硬化症中的人类白细胞抗原

HLA antigens in multiple sclerosis.

作者信息

Thorsby E, Helgesen A, Solheim B G, Vandvik B

出版信息

J Neurol Sci. 1977 Jun;32(2):187-93. doi: 10.1016/0022-510x(77)90233-7.

Abstract

The frequency of the MLC activating HLA-Dw2 determinant was found significantly increased to 68% among 37 patients with long-standing multiple sclerosis, compared to 30.2% among healthy controls. A similar (or stronger) degree of association was found with an "Ia-like" B cell specificity, SOW, while the association with HLA-B7 was less apparent. No correlation between HLA-Dw2 and signs of local synthesis of oligoclonal IgG or measles or rubella virus antibodies in the CNS was observed.

摘要

在37例长期患多发性硬化症的患者中，发现MLC激活HLA-Dw2决定簇的频率显著增加至68%，而健康对照者中的这一频率为30.2%。发现与一种“Ia样”B细胞特异性SOW存在相似（或更强）程度的关联，而与HLA-B7的关联则不太明显。未观察到HLA-Dw2与中枢神经系统中寡克隆IgG或麻疹或风疹病毒抗体的局部合成迹象之间存在相关性。