多发性硬化症中的人类白细胞抗原。与麻疹抗体、丝裂原反应性及临床病程的关系。

HLA in multiple sclerosis. Relationship to measles antibody, mitogen responsiveness and clinical course.

作者信息

Paty D W, Dossetor J B, Stiller C R, Cousin H K, Marchuk L, Furesz J, Boucher D W

出版信息

J Neurol Sci. 1977 Jul;32(3):371-9. doi: 10.1016/0022-510x(77)90020-x.

Abstract

In our study of multiple sclerosis (MS) patients we have found significant increases in the A3, B7, and DW2 antigens. We have also studied immune responses in these same patients. There was elevation of measles antibodies in MS patients positive for A3, B7, and B18 as compared to MS patients without those antigens. The first study of mitogen responsiveness (31 patients) showed a decreased response in A3, and B7 positive patients. Study of a second and a larger group (62 patients), at a different time, failed to confirm this deficiency. We propose that there is a genetically linked (HLA) T cell deficiency in some MS patients and that this deficiency results in high humoral responses to measles antigens and an evanescent (or cyclical) reduced T cell response to mitogen.

摘要

在我们对多发性硬化症（MS）患者的研究中，我们发现A3、B7和DW2抗原显著增加。我们还研究了这些患者的免疫反应。与没有这些抗原的MS患者相比，A3、B7和B18呈阳性的MS患者中麻疹抗体升高。对有丝分裂原反应性的首次研究（31名患者）显示，A3和B7阳性患者的反应降低。在不同时间对第二组且规模更大的患者（62名患者）进行的研究未能证实这种缺陷。我们提出，一些MS患者存在与基因相关（HLA）的T细胞缺陷，这种缺陷导致对麻疹抗原的高体液反应以及对有丝分裂原的短暂（或周期性）T细胞反应降低。