Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Department of Neonatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Sci Rep. 2018 Aug 29;8(1):13021. doi: 10.1038/s41598-018-31283-y.
Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China. A total of 194 paired maternal and cord blood samples were collected in Beijing from 2016 to 2017. Antibodies specific for the antigens covered by diphtheria-tetanus-pertussis (DTP) and measles-mumps-rubella (MMR) vaccine were determined by ELISA (Euroimmun, Lübeck, Germany). The cut off value of ≥0.1 IU/ml (anti-diphtheria), >0.1 IU/ml (anti-tetanus), >40 IU/ml (anti-pertussis toxin), ≥200 IU/l (anti-measles), ≥45 RU/ml (anti-mumps) and ≥10 IU/ml (anti-rubella) were used to assess the percentage of newborns with protective IgG concentrations, respectively. The results revealed that 61.3%, 73.2%, 97.4%, 30.4%, 65.5% and 17.0% of newborns had no protection against diphtheria, tetanus, pertussis, measles, mumps and rubella. Only 1.0% and 23.7% of newborns had protection against all three components of DTP or MMR, respectively. The finding suggested that most of newborns were susceptible to diphtheria, tetanus, pertussis and mumps, almost one-third of this population had no immune protection against measles, and about one-sixth of them were under threat of rubella infection. These data supported the immunization program for DTP and MMR vaccine in women at child-bearing age.
母体抗体有助于保护婴幼儿免受生命早期的传染病的侵害。然而，在中国，针对育龄妇女的疫苗接种并不是常规的。因此，我们调查了中国孕妇和新生儿对疫苗可预防疾病的保护性免疫水平。2016 年至 2017 年，我们在北京共采集了 194 对母婴配对的母血和脐血样本。采用酶联免疫吸附试验（Euroimmun，吕贝克，德国）检测针对白喉-破伤风-百日咳（DTP）和麻疹-腮腺炎-风疹（MMR）疫苗抗原的特异性抗体。采用≥0.1 IU/ml（抗白喉）、>0.1 IU/ml（抗破伤风）、>40 IU/ml（抗百日咳毒素）、≥200 IU/l（抗麻疹）、≥45 RU/ml（抗腮腺炎）和≥10 IU/ml（抗风疹）的截断值来评估新生儿保护性 IgG 浓度的百分比。结果显示，61.3%、73.2%、97.4%、30.4%、65.5%和 17.0%的新生儿对白喉、破伤风、百日咳、麻疹、腮腺炎和风疹无保护作用。只有 1.0%和 23.7%的新生儿对 DTP 或 MMR 的三种成分均有保护作用。结果表明，大多数新生儿易感染白喉、破伤风、百日咳和腮腺炎，近三分之一的人群对麻疹无免疫保护作用，约六分之一的人面临风疹感染的威胁。这些数据支持对育龄妇女进行 DTP 和 MMR 疫苗的免疫接种计划。
