Link H, Laurenzi M A, Frydén A
J Neuroimmunol. 1981 Sep;1(3):287-98. doi: 10.1016/0165-5728(81)90032-1.
The occurrence of viral antibodies in relation to IgG separated by thin-layer polyacrylamide gel isoelectric focusing was studied in CSF and serum from 24 patients with mumps meningitis by immunofixation with viral antigens and autoradiography. Eleven of the patients displayed on the autoradiograms evidence of locally in the central nervous system synthesized mumps virus antibodies which were related to oligoclonal IgG bands in all 5 patients who displayed this CSF abnormality, otherwise to polyclonal IgG bands. Local synthesis of mumps virus antibodies was detectable in 43% of specimens obtained 1-13 days after onset, and in 75% obtained 27-47 days after onset. Only one patient displayed local synthesis of antibodies to other viruses (measles and herpes simplex) which could then be traced to polyclonal IgG bands.
通过用病毒抗原进行免疫固定和放射自显影，研究了24例腮腺炎脑膜炎患者脑脊液和血清中与通过薄层聚丙烯酰胺凝胶等电聚焦分离的IgG相关的病毒抗体的出现情况。11例患者的放射自显影片显示，在中枢神经系统局部合成的腮腺炎病毒抗体，在所有出现脑脊液异常的5例患者中与寡克隆IgG带相关，在其他患者中与多克隆IgG带相关。在发病后1 - 13天获得的标本中，43%可检测到腮腺炎病毒抗体的局部合成，在发病后27 - 47天获得的标本中，75%可检测到。只有1例患者显示出针对其他病毒（麻疹和单纯疱疹病毒）的抗体局部合成，随后可追溯到多克隆IgG带。
