8型腺病毒角膜结膜炎——一次暴发及其局部用人成纤维细胞干扰素治疗
Adenovirus type 8 keratoconjunctivitis--an outbreak and its treatment with topical human fibroblast interferon.
作者信息
Reilly S, Dhillon B J, Nkanza K M, D'Souza A M, Taylor N, Hobbs S J, Freke A, Roome A P
出版信息
J Hyg (Lond). 1986 Jun;96(3):557-75. doi: 10.1017/s0022172400066365.
Abstract
An outbreak of keratoconjunctivitis is described which involved at least 186 people; adenovirus type 8 was identified in 50 of the cases. Topical human fibroblast interferon was assessed in a double-blind, placebo-controlled study in which 34 patients participated. Seventeen of the 34 trial patients yielded adenovirus type 8; three were infected with adenovirus type 7. The outbreak was curtailed by control of infection measures: principally careful hand-washing by medical personnel between cases and by discouraging attendance of new cases at the Eye Infirmary. Consequently the trial numbers are small. In addition there was a wide interpatient variation in the severity of infection. Therefore it was not possible to make any statistically valid conclusions concerning the recovery rate of patients receiving interferon or placebo.
摘要
本文描述了一起涉及至少186人的角结膜炎暴发疫情；50例病例中检测出8型腺病毒。在一项双盲、安慰剂对照研究中，对34名患者使用了局部人成纤维细胞干扰素进行评估。34名试验患者中有17例感染8型腺病毒；3例感染7型腺病毒。通过感染控制措施，疫情得到了控制：主要是医护人员在接触不同病例之间仔细洗手，并劝阻新病例前往眼科医院就诊。因此，试验样本量较小。此外，患者之间感染严重程度差异很大。因此，无法就接受干扰素或安慰剂治疗的患者的恢复率得出任何具有统计学意义的有效结论。
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