Darougar S, Grey R H, Thaker U, McSwiggan D A
Br J Ophthalmol. 1983 Jan;67(1):1-7. doi: 10.1136/bjo.67.1.1.
Ninety-eight patients were studied. Ninety were consecutive patients who were isolation-positive for adenovirus, and 8, who were associated with a hospital outbreak of adenovirus serotype 8 infection, developed characteristic features of infection but were isolation-negative. The ratio of males to females was 2 to 1, and most patients were aged 20 to 39. Adenovirus serotypes 3, 7, and 8 were isolated from 86% of patients, and serotypes 2, 4, 5, 11, 15, and 15/29 from the remaining 14%. Adenovirus serotype 7 was more commonly isolated from patients under the age of 19 and was Not isolated during winter. Sources of infection could be identified in 36% of patients and included contact with upper respiratory tract of ocular infections, a hospital outbreak, and a recent visit to a swimming pool. Associated systemic disease was detected in 47% of patients, most of whom had upper respiratory tract infection. The most severe and prolonged conjunctivitis was caused by serotypes 5 and 8. Most patients developed epithelial punctate keratitis. Subepithelial punctate keratitis, which was once-considered to be a characteristic feature of adenovirus serotype 8, developed in cases of serotype 3, 4, 5, 7, and 8 infection.
对98名患者进行了研究。其中90名是腺病毒分离呈阳性的连续患者，另外8名与医院腺病毒8型感染暴发有关，出现了感染的特征性表现，但分离结果为阴性。男女比例为2比1，大多数患者年龄在20至39岁之间。86%的患者分离出腺病毒3型、7型和8型，其余14%的患者分离出腺病毒2型、4型、5型、11型、15型和15/29型。腺病毒7型更常见于19岁以下的患者，且在冬季未分离到。36%的患者可确定感染源，包括与眼部感染的上呼吸道接触、医院暴发以及近期去过游泳池。47%的患者检测到相关的全身性疾病，其中大多数患有上呼吸道感染。最严重和持续时间最长的结膜炎由5型和8型引起。大多数患者出现上皮点状角膜炎。曾被认为是腺病毒8型特征性表现的上皮下点状角膜炎，在3型、4型、5型、7型和8型感染病例中也会出现。
