Departments of Clinical Sciences and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Departments of Clinical Sciences and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Gastroenterology. 2018 Dec;155(6):1716-1719.e4. doi: 10.1053/j.gastro.2018.07.045. Epub 2018 Aug 27.
The increasing incidence of colorectal cancer in younger adults (aged <50 years) has been widely reported. Using data from the Surveillance, Epidemiology, and End Results Program, we found young-onset colorectal cancer incidence rates decreased from 1975 through about 1990. Decreases were more prominent in the colon, a contrast with more recent increases in rectal cancer. Incidence rates subsequently increased, differing by time period and 5-year age group. This inflection point is consistent with a birth cohort effect and points to early life exposures-accumulated throughout the life course-that may increase cancer risk. Studying early life exposures among persons born after 1960 may advance our understanding of colorectal cancer in younger adults.
越来越多的研究报告指出，年轻人（<50 岁）中结直肠癌的发病率正在上升。我们利用监测、流行病学和最终结果计划的数据发现，年轻人结直肠癌的发病率从 1975 年到 1990 年期间有所下降。与最近直肠癌发病率上升形成对比的是，结肠癌的发病率下降更为明显。随后，发病率随时间和 5 岁年龄组而增加。这一拐点与出生队列效应一致，表明一生中积累的早期生活暴露可能会增加癌症风险。研究 1960 年后出生的人群的早期生活暴露情况可能会增进我们对年轻人结直肠癌的认识。
