Svensson E, Møller B, Tretli S, Barlow L, Engholm G, Pukkala E, Rahu M, Tryggvadóttir L, Langmark F, Grotmol T
Cancer Registry of Norway--Institute of Population-based Cancer Research, Montebello, Oslo, Norway.
Cancer Causes Control. 2005 Apr;16(3):215-23. doi: 10.1007/s10552-004-3073-x.
A lowering of colorectal cancer risk for the birth cohorts born around World War II (WWII) has previously been observed in Norway, a country which suffered some 20% caloric restriction during the war. The purpose of the study was to conduct a similar kind of analysis in the other Nordic countries and Estonia, which were also subjected to various degrees of energy restriction during WWII.
All new cases of colorectal cancer in the Nordic countries and Estonia diagnosed between 40 and 84 years of age and born between 1874 and 1953, were collected from the national cancer registries. The incidence data were fitted to an age-period-cohort model.
A transient drop in the estimated colorectal cancer incidence rate was observed for the birth cohorts born around WWII in Estonia, together with a tendency of decreased risk in Sweden and Denmark.
The previously observed lowering of colorectal cancer risk for persons born during WWII in Norway also prevails in Estonia. Energy restriction is a possible explanation for these findings, since the countries suffered from varying nutritional conditions during the war. Exogenous factors acting during periods early in life may have an impact on later colorectal cancer risk.
此前在挪威观察到，第二次世界大战（二战）前后出生的人群患结直肠癌的风险有所降低，该国在战争期间遭受了约20%的热量限制。本研究的目的是在其他北欧国家和爱沙尼亚进行类似分析，这些国家在二战期间也受到了不同程度的能量限制。
从国家癌症登记处收集北欧国家和爱沙尼亚40至84岁、出生于1874年至1953年之间的所有新诊断结直肠癌病例。将发病率数据拟合到年龄-时期-队列模型。
爱沙尼亚二战前后出生的队列中，估计的结直肠癌发病率出现短暂下降，瑞典和丹麦也有风险降低的趋势。
挪威此前观察到的二战期间出生人群患结直肠癌风险降低的情况在爱沙尼亚也存在。能量限制可能是这些发现的一个解释，因为这些国家在战争期间营养状况各不相同。生命早期阶段的外部因素可能会影响后期患结直肠癌的风险。
