London W T, Martinez A J, Houff S A, Wallen W C, Curfman B L, Traub R G, Sever J L
Teratology. 1986 Jun;33(3):323-31. doi: 10.1002/tera.1420330311.
Cytomegalovirus (CMV) infections occur worldwide and are responsible for severe damage to the child in from one to five newborns per 20,000 births. Animal models of congenital CMV infection resulting in disease have been developed in mice and guinea pigs. We report here the development of ventricular dilatation and leptomeningitis in rhesus monkeys, Macaca mulatta, following intrauterine infection with rhesus cytomegalovirus (RCMV). Central nervous system (CNS) lesions were associated with low cytomegalovirus fluorescent antibody titers in affected fetuses. In several infected animals, RCMV was isolated at necropsy from neural and nonneural tissues taken shortly after birth. This model allows investigators to study the pathogenesis and prevention of CNS changes following RCMV infection.
巨细胞病毒（CMV）感染在全球范围内都有发生，每20000例出生中就有1至5例新生儿因该病毒遭受严重损害。在小鼠和豚鼠身上已建立了导致疾病的先天性CMV感染动物模型。我们在此报告，恒河猴（猕猴）在宫内感染恒河猴巨细胞病毒（RCMV）后出现了心室扩张和软脑膜炎。中枢神经系统（CNS）病变与受感染胎儿体内低水平的巨细胞病毒荧光抗体滴度相关。在几只受感染的动物中，尸检时从出生后不久采集的神经组织和非神经组织中分离出了RCMV。该模型使研究人员能够研究RCMV感染后CNS变化的发病机制及预防措施。
