Kolekar Ketan, Tambe Swagata, Aderao Rashmi, Nayak Chitra
Department of Dermatology, Topiwala National Medical College & B.Y.L. Nair Hospital, Mumbai, India.
Int J STD AIDS. 2019 Jan;30(1):90-93. doi: 10.1177/0956462418792113. Epub 2018 Aug 31.
Candida, a commensal dimorphic fungus, is the most common microorganism that causes opportunistic fungal infections worldwide. It can cause diseases ranging from superficial mucosal infections to disseminated, systemic life-threatening infections. Among Candida species, Candida albicans is the most common infectious agent. Nowadays, non- albicans Candida species are also emerging as significant pathogens. Candida dubliniensis has been implicated as a causative agent of oral candidiasis in HIV-infected individuals but has also been recovered from HIV non-infected individuals with oral candidiasis and rarely from the genital tract of women with vaginitis. Such cases have been under-reported due to phenotypic resemblance to C. albicans. The majority of C. dubliniensis clinical isolates tested to date have been susceptible to fluconazole, but they tend to develop resistance rapidly. Here, we report a case of chronic vulvovaginitis due to C. dubliniensis not responding to standard doses of fluconazole.
念珠菌是一种共生双相真菌，是全球范围内引起机会性真菌感染最常见的微生物。它可引发从浅表黏膜感染到播散性、危及生命的全身性感染等多种疾病。在念珠菌属中，白色念珠菌是最常见的感染病原体。如今，非白色念珠菌也逐渐成为重要的病原体。都柏林念珠菌被认为是人类免疫缺陷病毒（HIV）感染者口腔念珠菌病的病原体，但也可从患口腔念珠菌病的非HIV感染者中分离得到，在患阴道炎的女性生殖道中则很少发现。由于其表型与白色念珠菌相似，此类病例报告较少。迄今为止，大多数检测的都柏林念珠菌临床分离株对氟康唑敏感，但它们往往会迅速产生耐药性。在此，我们报告一例由都柏林念珠菌引起的慢性外阴阴道炎病例，该病例对标准剂量的氟康唑无反应。
