Centro per la Prevenzione e Cura del Tabagismo (CPCT), Azienda Ospedaliero-Universitaria "Policlinico-V. Emanuele", Università di Catania, Catania, Italy.
Dipartimento di Medicina Clinica e Sperimentale, Università di Catania, Catania, Italy.
Respir Res. 2018 Aug 31;19(1):164. doi: 10.1186/s12931-018-0867-z.
Heated tobacco products (HTPs) are new tech devices that release nicotine and other volatile compounds into an inhalable aerosol by heating the tobacco. At their operating temperatures, tobacco combustion is unlikely.The aim of this randomized cross-over study was to measure the exposure levels of the combustion marker, carbon monoxide in the exhaled breath (eCO) of subjects after use of two HTPs and to compare these levels with participants' own brand of cigarettes.A total of 12 healthy smokers who reported smoking ≥10 conventional cigarettes per day for at least 5 years took part in the study. Product administration consisted of a first round of 10 puffs, which was followed by an identical second round after a 5 min pause in between rounds. After obtaining a baseline eCO value, this measure was recorded at 5, 10, 15, 30, and 45 min after the first puff of the first round. In contrast to combustible cigarettes, no eCO elevations were observed in the exhaled breath after use of the HTPs under investigation in any of the study participants.
加热烟草制品（HTPs）是一种新型技术设备，通过加热烟草将尼古丁和其他挥发性化合物释放到可吸入的气溶胶中。在其工作温度下，烟草不太可能燃烧。本随机交叉研究的目的是测量两种 HTP 使用后呼出的呼吸（eCO）中燃烧标志物一氧化碳的暴露水平，并将这些水平与参与者自己品牌的香烟进行比较。共有 12 名健康吸烟者参加了这项研究，他们报告说每天至少吸 10 支传统香烟，吸烟时间至少 5 年。产品管理包括第一轮抽吸 10 口，每轮之间休息 5 分钟，然后进行第二轮抽吸 10 口。在获得基线 eCO 值后，在第一轮第一口抽吸后 5、10、15、30 和 45 分钟记录该测量值。与可燃香烟不同，在任何研究参与者中，使用所研究的 HTP 后，呼出的呼吸中均未观察到 eCO 升高。
