Kitamura Yoshiaki, Moribe Shuichi, Kitade Yukio
Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Bioorg Med Chem Lett. 2018 Oct 15;28(19):3174-3176. doi: 10.1016/j.bmcl.2018.08.024. Epub 2018 Aug 25.
Glucosamino nucleic acids (GANAs) bearing a β-N-glycoside bond between carbon 1 of the glucosamine and the nucleobase nitrogen were synthesized and incorporated into oligonucleotides (4',6'-GANA and 3',6'-GANA). The thermal stability of oligonucleotide duplexes containing the GANA zwitterionic nucleotides was also investigated.
合成了在葡糖胺的1位碳与核碱基氮之间带有β-N-糖苷键的葡糖胺核酸（GANA），并将其掺入寡核苷酸中（4',6'-GANA和3',6'-GANA）。还研究了含有GANA两性离子核苷酸的寡核苷酸双链体的热稳定性。
