Endodontics Division, Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland Baltimore, Maryland.
Biomaterials and Tissue Engineering Division, Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland Baltimore, Maryland.
J Endod. 2018 Oct;44(10):1553-1557. doi: 10.1016/j.joen.2018.06.016. Epub 2018 Aug 31.
The purpose of this study was to investigate the physical and antibacterial properties of a resin sealer mixed with a quaternary ammonium compound, dimethylaminododecyl methacrylate (DMAHDM) and nanosilver (NAg).
A pilot study was completed to determine the highest concentrations of DMAHDM and NAg that did not significantly alter the physical properties (setting time, flow, solubility, and dimensional change) of AH Plus (Dentsply Sirona, York, PA) when added to the sealer. These concentrations were selected to create a modified resin sealer (mAH Plus). A modified direct contact test evaluated antibacterial properties of AH Plus, DMAHDM + AH Plus, NAg + AH Plus, and mAH Plus at days 1, 7, and 14 against Enterococcus faecalis.
Concentrations of 2.5% DMAHDM and 0.15% NAg were added to AH Plus. The flow of mAH Plus was significantly decreased but still within American National Standards Institute/American Dental Association specifications. There were no significant differences in setting time, solubility, or dimensional change. On day 1, 0.15% NAg + AH Plus, 2.5% DMAHDM + AH Plus, and mAH Plus were significantly more effective against E. faecalis compared with AH Plus (P < .05). On days 7 through 14, 2.5% DMAHDM + AH Plus and mAH Plus continued to be significantly more antibacterial than AH Plus (P < .05).
The addition of 0.15% NAg and 2.5% DMAHDM did not adversely affect the physical properties of AH Plus, and mAH Plus was significantly more antibacterial against E. faecalis.
本研究旨在探究一种混合了季铵盐化合物（二甲氨基十二烷基甲基丙烯酸酯，DMAHDM）和纳米银（NAg）的树脂密封剂的物理性能和抗菌性能。
进行了一项初步研究，以确定当添加到密封剂中时，DMAHDM 和 NAg 的最高浓度不会显著改变 AH Plus（Dentsply Sirona，约克，PA）的物理性质（凝固时间、流动性、溶解度和尺寸变化）。选择这些浓度来创建改良树脂密封剂（mAH Plus）。改良直接接触试验评估了 AH Plus、DMAHDM+AH Plus、NAg+AH Plus 和 mAH Plus 在第 1、7 和 14 天对粪肠球菌的抗菌性能。
向 AH Plus 中添加 2.5%的 DMAHDM 和 0.15%的 NAg。mAH Plus 的流动性显著降低，但仍在美国国家标准协会/美国牙科协会规格范围内。凝固时间、溶解度或尺寸变化无显著差异。第 1 天，0.15%NAg+AH Plus、2.5%DMAHDM+AH Plus 和 mAH Plus 对粪肠球菌的抗菌效果明显优于 AH Plus（P<.05）。第 7 天至 14 天，2.5%DMAHDM+AH Plus 和 mAH Plus 持续对粪肠球菌具有更强的抗菌作用，明显优于 AH Plus（P<.05）。
添加 0.15%NAg 和 2.5%DMAHDM 不会对 AH Plus 的物理性能产生不利影响，mAH Plus 对粪肠球菌具有更强的抗菌作用。
