Crippa Sylvain V, Pedrosa Domellöf Fatima, Kawasaki Aki
Neuro-Ophthalmology Unit, Jules-Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
Group for Retinal Disorder Research, Jules-Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
Front Neurol. 2018 Aug 17;9:669. doi: 10.3389/fneur.2018.00669. eCollection 2018.
Chromatic pupillometry is a technique that is increasingly used to assess retinal disorders. As age may be one of the various factors which can influence the pupillary light reaction, this study aimed to evaluate the pupil responses to colored light stimuli in the pediatric population. Fifty-three children with normal vision and without any history of ocular disorders were tested with a portable pupillometer. Four test sequences were used: five dim blue (470 nm) stimuli presented in half log steps ranging from -3.15 to -1.15 log cd/m after 3 min of dark adaptation, five red (622 nm) stimuli of -1.15, -0.7, -0.15, 0.3, and 0.85 log cd/m after 1 min light adaptation, one bright blue stimulus of 2.2 log cd/m and one bright red of 2 log cd/m. The results were grouped by age: a younger group included 27 children aged from 3 to 10 years old and an older group included 26 from 10 and 1 month to 18 years old. The younger group had a smaller pupil diameter after dark adaptation compared with the older group. A linear regression defining the photopic threshold showed that younger subjects had a higher threshold, e.g., needed a brighter red stimulus to evoke a threshold pupil response comparable that of subjects. Age thus seems to influence outer retinal sensitivity at least as evaluated by the pupillary photopic threshold intensity. The post-illumination pupillary reaction was used as a marker of intrinsic melanopsin activity and did not show any difference between the two age groups.
彩色瞳孔测量法是一种越来越多地用于评估视网膜疾病的技术。由于年龄可能是影响瞳孔光反应的多种因素之一，本研究旨在评估儿童群体对彩色光刺激的瞳孔反应。使用便携式瞳孔计对53名视力正常且无眼部疾病史的儿童进行了测试。采用了四个测试序列：在暗适应3分钟后，以半对数步长呈现五个暗蓝色（470纳米）刺激，范围从-3.15至-1.15 log cd/m²；在明适应1分钟后，呈现五个红色（622纳米）刺激，强度分别为-1.15、-0.7、-0.15、0.3和0.85 log cd/m²；一个强度为2.2 log cd/m²的亮蓝色刺激和一个强度为2 log cd/m²的亮红色刺激。结果按年龄分组：较年轻组包括27名年龄在3至10岁的儿童，较年长组包括26名年龄在10岁1个月至18岁的儿童。与较年长组相比，较年轻组在暗适应后的瞳孔直径较小。定义明视觉阈值的线性回归显示，较年轻的受试者阈值较高，例如，需要更亮的红色刺激才能引发与年长受试者相当的阈值瞳孔反应。因此，至少从瞳孔明视觉阈值强度评估来看，年龄似乎会影响视网膜外层的敏感性。光照后瞳孔反应被用作内在黑视蛋白活性的标志物，在两个年龄组之间未显示出任何差异。
