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内质网：下一代癌症治疗的靶点。

Endoplasmic Reticulum: Target for Next-Generation Cancer Therapy.

机构信息

Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

出版信息

Chembiochem. 2018 Nov 16;19(22):2341-2343. doi: 10.1002/cbic.201800461. Epub 2018 Oct 15.

DOI:10.1002/cbic.201800461
PMID:30176182
Abstract

Tumour-targeting and selective ER stress inducers: Small-molecule compounds that target the endoplasmic reticulum (ER) and induce ER stress are emerging as next-generation anticancer agents. This highlight discusses a few current works on this topic and its enormous potential in the fight against cancer.

摘要

肿瘤靶向和选择性内质网应激诱导剂

靶向内质网 (ER) 并诱导 ER 应激的小分子化合物正在成为新一代抗癌药物。本文重点讨论了这一主题的一些最新研究进展及其在抗癌方面的巨大潜力。

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Endoplasmic Reticulum: Target for Next-Generation Cancer Therapy.内质网：下一代癌症治疗的靶点。
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The unfolded protein response as a target for anticancer therapeutics.未折叠蛋白反应作为抗癌治疗的靶点。
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Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress.漆树酸诱导细胞凋亡与诱导 ATF4 依赖性内质网应激有关。
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