Soares Sara, Sousa João, Pais Alberto, Vitorino Carla
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Front Chem. 2018 Aug 20;6:360. doi: 10.3389/fchem.2018.00360. eCollection 2018.
Several scientific areas have benefited significantly from the introduction of nanotechnology and the respective evolution. This is especially noteworthy in the development of new drug substances and products. This review focuses on the introduction of nanomedicines in the pharmaceutical market, and all the controversy associated to basic concepts related to these nanosystems, and the numerous methodologies applied for enhanced knowledge. Due to the properties conferred by the nanoscale, the challenges for nanotechnology implementation, specifically in the pharmaceutical development of new drug products and respective regulatory issues are critically discussed, mainly focused on the European Union context. Finally, issues pertaining to the current applications and future developments are presented.
纳米技术的引入及其相应的发展使多个科学领域受益匪浅。这在新药物和产品的开发中尤为显著。本综述聚焦于纳米药物在医药市场的引入、与这些纳米系统基本概念相关的所有争议，以及为增进认识而应用的众多方法。由于纳米尺度赋予的特性，本文批判性地讨论了纳米技术实施面临的挑战，特别是在新药品的药物研发及相关监管问题方面，主要聚焦于欧盟背景。最后，介绍了当前应用和未来发展相关的问题。
