Zahirnia Zahra, Mansouri Shahla, Saffari Fereshteh
Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran.
Wien Med Wochenschr. 2019 Jun;169(9-10):226-231. doi: 10.1007/s10354-018-0648-9. Epub 2018 Sep 3.
Listeria monocytogenes is a foodborne pathogen that can pose serious complications during pregnancy and neonatal infection. This study aimed to determine the frequency of L. monocytogenes infection, prevalent serotypes, and virulence genes among pregnant women and those experiencing miscarriages in Kerman, Iran. Out of 200 vaginal swabs, 4.5 and 29.5% of specimens were positive for L. monocytogenes infection as identified by culture and molecular methods, respectively. The majority of isolates from positive cultures (89%) of pregnant women resulted in stillbirth, death, and blindness. The most prevalent virulence determinants were inl B, prf A, and act A. The majority of isolates were non-typable. A history of miscarriage and gestational age are known to be significantly associated with the presence of infection. This study emphasizes the importance of initial screening for L. monocytogenes in pregnant women in Iran. Molecular methods may be useful in this process. Increasing the awareness of pregnant women could be effective in reducing pregnancy-related listeriosis.
单核细胞增生李斯特菌是一种食源性病原体，在孕期和新生儿感染期间可引发严重并发症。本研究旨在确定伊朗克尔曼地区孕妇和流产女性中单核细胞增生李斯特菌感染的频率、流行血清型及毒力基因。在200份阴道拭子中，分别通过培养和分子方法鉴定出，4.5%和29.5%的标本单核细胞增生李斯特菌感染呈阳性。孕妇阳性培养物中的大多数分离株（89%）导致死产、死亡和失明。最常见的毒力决定因素是inl B、prf A和act A。大多数分离株无法分型。已知流产史和孕周与感染的存在显著相关。本研究强调了伊朗孕妇中单核细胞增生李斯特菌初始筛查的重要性。分子方法在此过程中可能有用。提高孕妇的认识可能有助于减少与妊娠相关的李斯特菌病。
