Kaczmarek Katarzyna, Hornowski Tomasz, Dobosz Bernadeta, Józefczak Arkadiusz
Institute of Acoustics, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61⁻614 Poznań, Poland.
Medical Physics Division, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61⁻614 Poznań, Poland.
Materials (Basel). 2018 Sep 4;11(9):1607. doi: 10.3390/ma11091607.
Ultrasound hyperthermia is a medical treatment used to increase temperature of tissues. It can be used independently or as a supportive method for an anticancer treatment. The therapeutic efficacy of focused ultrasound hyperthermia can be improved using sonosensitizers, nanoparticles enhancing the attenuation and dissipation of acoustic energy. As sonosensitizers, we propose magnetic nanoparticles owing to their biodegradability, biocompatibility, and simple positioning in tissues using a magnetic field. Focused ultrasound hyperthermia studies were performed using tissue-mimicking phantoms. Temperature changes were measured at various ultrasound powers and distances from the center of the ultrasound focus. Specific absorption rate (SAR) values, describing the power deposition in the tissues during the hyperthermia treatment, were evaluated for the center of the focus point and for various distances from it. The results show that the addition of nanoparticles increases the SAR almost two times compared to that for the pure phantom. The highest SAR is obtained in the ultrasound focus; it decreases with the increase of the distance from the focus.
超声热疗是一种用于提高组织温度的医学治疗方法。它可以单独使用，也可以作为抗癌治疗的辅助方法。使用声敏剂、能增强声能衰减和耗散的纳米颗粒，可以提高聚焦超声热疗的治疗效果。作为声敏剂，我们提出使用磁性纳米颗粒，因为它们具有生物可降解性、生物相容性，并且可以通过磁场在组织中简单定位。使用仿组织体模进行了聚焦超声热疗研究。在不同的超声功率和距超声焦点中心的不同距离处测量温度变化。针对焦点中心及其不同距离处，评估了描述热疗治疗期间组织中功率沉积的比吸收率（SAR）值。结果表明，与纯体模相比，添加纳米颗粒后SAR几乎增加了两倍。在超声焦点处获得最高的SAR；它随着与焦点距离的增加而降低。
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