Department of Urology, Kyungpook National University Hospital, Daegu, Korea.
Department of Urology, Kyungpook National University Chilgok Hospital, Daegu, Korea.
Investig Clin Urol. 2018 Sep;59(5):335-341. doi: 10.4111/icu.2018.59.5.335. Epub 2018 Jul 23.
Ureteroscopic lithotripsy (URS) is gaining popularity for the management of ureteral stones and even renal stones, with high efficacy and minimal invasiveness. Although this procedure is known to be safe and to have a low complication rate, febrile urinary tract infection (UTI) after URS is not rare. Therefore, we aimed to analyze the risk factors and causative pathogens of febrile UTI after URS.
Between January 2013 and June 2015, 304 patients underwent URS for ureteral or renal stones. The rate of postoperative febrile UTI and the causative pathogens were verified, and the risk factors for postoperative febrile UTI were analyzed using logistic regression analysis.
Of 304 patients, postoperative febrile UTI occurred in 43 patients (14.1%). Of them, pathogens were cultured in blood or urine in 19 patients (44.2%), and definite pathogens were not identified in 24 patients (55.8%). In patients with an identified pathogen, had the highest incidence. Multivariate analysis showed that the operation time (p<0.001) was an independent risk factor for febrile UTI after URS. The cut-off value of operation time for increased risk of febrile UTI was 70 minutes.
Overall, febrile UTI after URS occurred in 14.1% of patients, and the operation time was an independent predictive factor for this complication. Considering that more than 83.7% of febrile UTIs after URS were not controlled with fluoroquinolones, it may be more appropriate to use higher-level antibiotics for treatment, even in cases with unidentified pathogens.
输尿管镜碎石术(URS)在治疗输尿管结石甚至肾结石方面越来越受欢迎,其具有高效性和微创性。虽然该手术已知是安全且并发症发生率低的,但 URS 术后发热性尿路感染(UTI)并不罕见。因此,我们旨在分析 URS 后发热性 UTI 的危险因素和病原体。
2013 年 1 月至 2015 年 6 月期间,有 304 例患者因输尿管或肾结石接受 URS。验证术后发热性 UTI 的发生率和病原体,并使用逻辑回归分析分析术后发热性 UTI 的危险因素。
304 例患者中,术后发热性 UTI 发生于 43 例(14.1%)。其中,19 例(44.2%)患者血或尿培养出病原体,24 例(55.8%)患者未明确病原体。明确病原体的患者中,大肠埃希菌的发生率最高。多变量分析显示,手术时间(p<0.001)是 URS 后发热性 UTI 的独立危险因素。手术时间的截值为 70 分钟,其增加发热性 UTI 的风险。
总体而言,URS 后发热性 UTI 的发生率为 14.1%,手术时间是该并发症的独立预测因素。由于 URS 后超过 83.7%的发热性 UTI 不能用氟喹诺酮类药物控制,因此,即使在未明确病原体的情况下,可能更适合使用更高水平的抗生素进行治疗。