Schaude M, Meingassner J G
J Med Vet Mycol. 1986 Aug;24(4):297-304. doi: 10.1080/02681218680000451.
Growth of the yeast form of Sporothrix schenckii (ATCC 14804) was determined in diffusion chambers with 0.45 and 3.0 micron pore size over a period of 24 to 192 h after subcutaneous implantation into mice. Numbers of S. schenckii in 0.45 micron chambers increased significantly by 192 h when inocula of 10(3) and 10(5) colony forming units were implanted. In chambers with a pore size of 3.0 microns, only a slight decrease of fungal growth occurred, although host cells readily passed the filter membrane and phagocytosed yeast-form cells. The activities of amphotericin B, ketoconazole, itraconazole, ICI 153.066, vibunazole and potassium iodide against S. schenckii in implanted chambers were determined in terms of their effects on S. schenckii. ICI 153.066, ketoconazole, itraconazole and amphotericin B significantly reduced the numbers of reisolated S. schenckii in both types of chambers. There was a slight activity with vibunazole but none with potassium iodide.
将申克孢子丝菌（ATCC 14804）的酵母形式接种到小鼠皮下后，在孔径为0.45微米和3.0微米的扩散小室中培养24至192小时，观察其生长情况。当接种10³和10⁵个菌落形成单位时，在孔径为0.45微米的小室中，申克孢子丝菌数量在192小时时显著增加。在孔径为3.0微米的小室中，尽管宿主细胞能轻易穿过滤膜并吞噬酵母形式的细胞，但真菌生长仅有轻微下降。根据两性霉素B、酮康唑、伊曲康唑、ICI 153.066、维邦唑和碘化钾对植入小室中的申克孢子丝菌的作用，测定了它们的活性。ICI 153.066、酮康唑、伊曲康唑和两性霉素B在两种类型的小室中均显著减少了重新分离出的申克孢子丝菌数量。维邦唑有轻微活性，而碘化钾则无活性。
