Tanabe Eloiza Lopes de Lira, Tanabe Ithallo Sathio Bessoni, Santos Elane Conceição Dos, Marques Juliana Paula da Silva, Borges Alessandra Abel, Lima Magliones Carneiro de, Anderson Letícia, Bassi Ênio José
Laboratório de Pesquisas em Virologia e Imunologia (LAPEVI), Grupo de Pesquisa em Regulação da Resposta Imune (IMUNOREG), Instituto de Ciências Biológicas e da Saúde (ICBS), Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.
Laboratório Central de Saúde Pública de Alagoas (LACEN/AL), Maceió, Alagoas, Brazil.
Rev Inst Med Trop Sao Paulo. 2018;60:e19. doi: 10.1590/s1678-9946201860019. Epub 2018 Apr 23.
Chikungunya virus (CHIKV) causes a self-limiting disease characterized by the onset of fever, skin rash and persistent arthralgia. In the last decade, it has emerged as a serious public health problem causing several outbreaks around the world. Here, we report the CHIKV genotype characterization during the 2016 CHIKV outbreak in Alagoas State, Brazil. Partial E1 sequence from CHIKV-positive samples coming from different cities of Alagoas were submitted to DNA sequencing followed by phylogenetic analysis thus characterizing the virus genotype. The circulating CHIKV virus in Alagoas during 2016 outbreak belongs to the East-Central South African genotype. In this way, virus genotyping to monitoring the spread of CHIKV is needed to continued surveillance supporting the development of prevention strategies, mainly in endemic areas of mosquitoes and arboviruses co-circulation.
基孔肯雅病毒（CHIKV）引起一种自限性疾病，其特征为发热、皮疹和持续性关节痛。在过去十年中，它已成为一个严重的公共卫生问题，在全球引发了多次疫情。在此，我们报告了2016年巴西阿拉戈斯州基孔肯雅病毒疫情期间该病毒的基因型特征。来自阿拉戈斯不同城市的基孔肯雅病毒阳性样本的部分E1序列被送去进行DNA测序，随后进行系统发育分析，从而确定病毒的基因型。2016年疫情期间在阿拉戈斯传播的基孔肯雅病毒属于东中非南非基因型。因此，需要进行病毒基因分型以监测基孔肯雅病毒的传播，以便持续开展监测，支持预防策略的制定，主要是在蚊子和虫媒病毒共同传播的流行地区。
